Zhou Yulin, Zhao Liebin, Wang Tiange, Hong Jie, Zhang Jie, Xu Baihui, Huang Xiaolin, Xu Min, Bi Yufang
Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine.
J Atheroscler Thromb. 2016;23(2):216-24. doi: 10.5551/jat.30338. Epub 2015 Oct 1.
Increased carotid artery intima media thickness (C-IMT) is an early feature of atherosclerosis. It has been reported to be altered in patients with thyroid dysfunction, and the evidence is still controversial. The present study aimed to explore the relationship between C-IMT and possible variations in thyroid function in Chinese adults aged 40 years and above.
A community-based cross-sectional study was conducted among 2276 non-diabetic participants. Serum free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) were determined by chemiluminescent microparticle immunoassay.
The prevalence of elevated C-IMT decreased according to FT3 quartiles (29.8%, 24.3%, 24.2%, and 22.2%, P for trend=0.005). In both univariate and multivariate linear regression analyses, FT3 levels were inversely associated with C-IMT (both P values ≤ 0.002). Multivariate-adjusted logistic regression analysis showed that high FT3 levels were associated with low prevalent elevated C-IMT. The adjusted odds ratio for elevated C-IMT was 0.71 (95% confidence interval, 0.52-0.99, P=0.04) when comparing the highest with the lowest quartile of FT3.
Serum FT3 levels were inversely associated with elevated C-IMT in middle-aged and elderly Chinese adults without diabetes, independent of traditional risk factors for atherosclerosis.
颈动脉内膜中层厚度（C-IMT）增加是动脉粥样硬化的早期特征。据报道，甲状腺功能障碍患者的C-IMT会发生改变，但其证据仍存在争议。本研究旨在探讨40岁及以上中国成年人中C-IMT与甲状腺功能可能变化之间的关系。
对2276名非糖尿病参与者进行了一项基于社区的横断面研究。采用化学发光微粒子免疫分析法测定血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）和促甲状腺激素（TSH）。
C-IMT升高的患病率随FT3四分位数降低（分别为29.8%、24.3%、24.2%和22.2%，趋势P=0.005）。在单变量和多变量线性回归分析中，FT3水平均与C-IMT呈负相关（P值均≤0.002）。多变量调整后的逻辑回归分析显示，高FT3水平与低患病率的C-IMT升高相关。比较FT3最高四分位数与最低四分位数时，C-IMT升高的调整优势比为0.71（95%置信区间，0.52-0.99，P=0.04）。
在无糖尿病的中老年中国成年人中，血清FT3水平与C-IMT升高呈负相关，且独立于动脉粥样硬化的传统危险因素。
