Stanley Ashley, Chavda K, Subramanian A, Prabhu S V, Ashavaid T F
Research Laboratories, P. D. Hinduja Hospital and Medical Research Centre, Veer Savarkar Marg, Mahim, Mumbai, 400016 India.
Department of Medicine, P. D. Hinduja Hospital and Medical Research Centre, Veer Savarkar Marg, Mahim, Mumbai, 400016 India.
Indian J Clin Biochem. 2017 Jun;32(2):239-242. doi: 10.1007/s12291-016-0587-4. Epub 2016 Jun 24.
The dopamine receptor-D4 and the dopamine transporter have been investigated for their role in attention deficit hyperactivity disorder (ADHD) in children. Reports of their genetic association with ADHD have shown mixed results. The aim of the study was to evaluate the association of variable number tandem repeats (VNTRs) of the and genes with ADHD in children. A pilot 1:1 case control study, with 44 clinically confirmed ADHD cases and 44 age/gender matched healthy controls, was conducted at a tertiary care centre in Mumbai. Variable number tandem repeats of exon 3, intron 8 and 3'UTR were genotyped by PCR-AGE. Several allele repeats of the genes were observed in the screened subjects. Statistical significance was observed for the 10R/10R genotype of the 3'UTR VNTR between cases and controls.
多巴胺受体D4和多巴胺转运体在儿童注意力缺陷多动障碍（ADHD）中的作用已得到研究。关于它们与ADHD的基因关联的报告结果不一。本研究的目的是评估儿童中 和 基因的可变数目串联重复序列（VNTRs）与ADHD的关联。在孟买的一家三级医疗中心进行了一项初步的1:1病例对照研究，有44例临床确诊的ADHD病例和44例年龄/性别匹配的健康对照。通过PCR-AGE对 外显子3、 内含子8和3'UTR的可变数目串联重复序列进行基因分型。在筛查的受试者中观察到了这些基因的几个等位基因重复。病例组和对照组之间在 3'UTR VNTR的10R/10R基因型上观察到统计学显著性。
