Wang Dongyao, Cao Yan, Zheng Leyi, Lv Diya, Chen Langdong, Xing Xinrui, Zhu Zhenyu, Li Xiaoyu, Chai Yifeng
School of Pharmacy, Second Military Medical University, Shanghai, China.
Chem Commun (Camb). 2017 May 2;53(36):5020-5023. doi: 10.1039/c7cc02227a.
Matrine is a plant alkaloid and a major active component in the Chinese medical herb Sophora flavescens. Matrine has shown potent anti-cancer activities but its molecular target(s) and mechanism are still unknown. Using the photo-affinity labeling approach, for the first time, Annexin A2 was identified as a direct-binding target of matrine in cancer cells.
苦参碱是一种植物生物碱，也是中药材苦参中的主要活性成分。苦参碱已显示出强大的抗癌活性，但其分子靶点和作用机制仍不清楚。首次使用光亲和标记方法，鉴定出膜联蛋白A2是苦参碱在癌细胞中的直接结合靶点。
