Macartney L, Thompson H, McCandlish I A, Cornwell H J
Department of Veterinary Pathology, Glasgow University Veterinary School.
Vet Rec. 1988 Jun 11;122(24):573-6. doi: 10.1136/vr.122.24.573.
Two groups of puppies, one passively immunised by the administration of hyperimmune serum and the other with natural maternally derived antibody, were inoculated orally with virulent canine parvovirus of faecal origin. Serum antibody titres declined more rapidly in both groups after challenge than before. The dogs became clinically affected but the onset of clinical signs, seroconversion and faecal excretion of virus was delayed when compared to controls. It is postulated that this rapid decline of antibody was due to its sequestration by virus after the initial phase of viral replication in the lymphoid tissues. These findings have important implications. The incubation period of the disease is prolonged, making it more difficult to estimate accurately the time of infection in clinically affected animals. Furthermore, the more rapid decline of maternally derived antibody, which could occur in endemically infected premises, may complicate immunisation programmes based on the isolation and segregation of puppies in anticipation of a predicted decline in maternally derived antibody before vaccination.
两组幼犬，一组通过给予高免疫血清进行被动免疫，另一组具有天然母源抗体，经口接种粪便来源的强毒犬细小病毒。攻毒后两组血清抗体滴度均比攻毒前下降得更快。犬只出现临床症状，但与对照组相比，临床症状的出现、血清转化和病毒粪便排泄均延迟。据推测，抗体的这种快速下降是由于在淋巴组织中病毒复制的初始阶段后，抗体被病毒隔离所致。这些发现具有重要意义。疾病的潜伏期延长，使得准确估计临床感染动物的感染时间更加困难。此外，在地方性感染的场所可能出现的母源抗体更快下降，可能会使基于在预期疫苗接种前母源抗体预计下降之前隔离和分养幼犬的免疫程序复杂化。
