Iyer Divyaanka, Mishra Navya, Agrawal Anurag
CSIR Institute of Genomics and Integrative Biology, Delhi University campus, Mall Road, Delhi, 110007, India.
Indian Institute of Public Health, Gurugram, India.
Curr Allergy Asthma Rep. 2017 May;17(5):29. doi: 10.1007/s11882-017-0695-0.
The connections between allergy, asthma and metabolic syndrome are becoming increasingly clear. Recent research suggests a unifying mitochondrial link between the diverse phenotypes of these interlinked morbidities. The scope of this review is to highlight cellular mechanisms, epidemiology and environmental allergens influencing mitochondrial function and its importance in allergy and asthma. We briefly also consider the potential of mitochondria-targeted therapies in prevention and cure.
Recent research has shown allergy, asthma and metabolic syndrome to be linked to mitochondrial dysfunction. Environmental pollutants and allergens are observed to cause mitochondrial dysfunction, primarily by inducing oxidative stress and ROS production. Malfunctioning mitochondria change the bioenergetics of the cell and its metabolic profile to favour systemic inflammation, which drives all three types of morbidities. Given the existing experimental evidence, approaches targeting mitochondria (e.g. antioxidant therapy and mitochondrial replacement) are being conducted in relevant disease models-with some progressing towards clinical trials, making mitochondrial function the focus of translational therapy research in asthma, allergy and linked metabolic syndrome.
过敏、哮喘与代谢综合征之间的联系日益清晰。近期研究表明，这些相互关联的疾病的不同表型之间存在统一的线粒体联系。本综述的范围是突出影响线粒体功能的细胞机制、流行病学和环境过敏原，及其在过敏和哮喘中的重要性。我们还简要考虑了线粒体靶向疗法在预防和治疗中的潜力。
近期研究表明，过敏、哮喘和代谢综合征与线粒体功能障碍有关。观察到环境污染物和过敏原主要通过诱导氧化应激和活性氧生成来导致线粒体功能障碍。功能失调的线粒体改变细胞的生物能量学及其代谢谱，从而促进全身炎症，进而引发所有这三种类型的疾病。鉴于现有实验证据，针对线粒体的方法（如抗氧化疗法和线粒体替代）正在相关疾病模型中进行——有些已进入临床试验阶段，这使得线粒体功能成为哮喘、过敏及相关代谢综合征转化治疗研究的重点。
