Li X-C, Zeng Y, Sun R-R, Liu M, Chen S, Zhang P-Y
The Affiliated XuZhou Center Hospital of Nanjing University of Chinese Medicine, XuZhou Central Hospital, XuZhou, China.
Eur Rev Med Pharmacol Sci. 2017 Apr;21(7):1583-1587.
SUMOylation regulates diverse cellular processes including transcription, cell cycle, protein stability, and apoptosis. A recent research has now revealed the role of SUMO1 in cardiac disorders. Studies have evidenced that failing heart induces SUMO2/3 conjugation. Moreover, increased SUMO2/3- dependent modification has been observed to result in congestive heart disease such as cardiac hypertrophy by promoting cardiac cell death. Also, few recent studies have confirmed the role of SUMOylation in cardiac protein degradation. On the other hand, over-expression of SENP5, SUMO2/3-specific deconjugation enzyme has been observed to result in dilated cardiomyopathy or cardiac failure. So, the present review article would enlighten the latest updates about SUMOylation and associated factors during cardiac disorders.
SUMO化修饰调控多种细胞过程，包括转录、细胞周期、蛋白质稳定性和细胞凋亡。最近的一项研究揭示了SUMO1在心脏疾病中的作用。研究表明，衰竭心脏会诱导SUMO2/3缀合。此外，已观察到SUMO2/3依赖性修饰增加会通过促进心肌细胞死亡导致充血性心脏病，如心肌肥大。而且，最近的一些研究证实了SUMO化修饰在心脏蛋白质降解中的作用。另一方面，已观察到SUMO2/3特异性去缀合酶SENP5的过表达会导致扩张型心肌病或心力衰竭。因此，本综述文章将阐述心脏疾病期间SUMO化修饰及相关因子的最新进展。
