Petrides Foivos E, Mavroudis Ioannis A, Spilioti Martha, Chatzinikolaou Fotios G, Costa Vasiliki G, Baloyannis Stavros J
1 Laboratory of Neuropathology, First Department of Neurology, AHEPA Hospital, Aristotelian University of Thessaloniki, Greece.
2 Institute of Alzheimer's disease Research, Heraklion Langada, Greece.
Am J Alzheimers Dis Other Demen. 2017 Jun;32(4):222-229. doi: 10.1177/1533317517703476. Epub 2017 Apr 21.
Alzheimer's disease (AD) is a progressive neurodegenerative disease that involves numerous cellular and biochemical mechanisms resulting in synaptic alterations and extensive neuronal loss. It is primarily characterized by impairment of memory, associated frequently with mood disorders. Continuous studies have shown that insula may be an important target of AD, but neuropathological alterations have not been described extensively. In the present study, we attempted to describe the morphometric and morphological changes of the spines of Reil insula in AD in comparison with normal aging using a silver impregnation technique. We classified spines into 3 types: (1) long neck, (2) short stubby, and (3) other types; and we measured and correlated the length of them in normal controls and in individuals with AD using ImageJ application. Statistical analysis was based on the Student t test on the basis of 360 cells in SPSS v.17.0, and significance was taken as P < .05.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，涉及众多细胞和生化机制，导致突触改变和广泛的神经元丢失。其主要特征是记忆受损，常伴有情绪障碍。持续研究表明，脑岛可能是AD的一个重要靶点，但神经病理学改变尚未得到广泛描述。在本研究中，我们试图使用银浸染技术，与正常衰老情况相比，描述AD患者脑岛Reil回棘的形态计量学和形态学变化。我们将棘分为3种类型：（1）长颈型，（2）短粗型，以及（3）其他类型；并使用ImageJ软件测量了正常对照组和AD患者棘的长度，并进行相关性分析。统计分析基于SPSS v.17.0软件中对360个细胞进行的Student t检验，显著性水平设定为P < 0.05。
