帕金森病：原位星形胶质细胞重编程——帕金森病中更简单的细胞替代疗法？ - Suppr

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超能文献

Parkinson disease: In situ astrocyte reprogramming - simpler cell replacement therapy in PD?

作者信息

Fyfe Ian

出版信息

Nat Rev Neurol. 2017 Jun;13(6):318-319. doi: 10.1038/nrneurol.2017.60. Epub 2017 Apr 21.

DOI:10.1038/nrneurol.2017.60

PMID:28429802

Abstract

摘要

相似文献

Parkinson disease: In situ astrocyte reprogramming - simpler cell replacement therapy in PD?帕金森病：原位星形胶质细胞重编程——帕金森病中更简单的细胞替代疗法？

Nat Rev Neurol. 2017 Jun;13(6):318-319. doi: 10.1038/nrneurol.2017.60. Epub 2017 Apr 21.

Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF.活化的星形胶质细胞通过碱性成纤维细胞生长因子增强干细胞的多巴胺能分化并促进脑修复。

Nat Commun. 2014 Dec 17;5:5627. doi: 10.1038/ncomms6627.

Regenerative medicine for Parkinson's disease using differentiated nerve cells derived from human buccal fat pad stem cells.使用源自人颊脂垫干细胞的分化神经细胞治疗帕金森病的再生医学。

Hum Cell. 2017 Apr;30(2):60-71. doi: 10.1007/s13577-017-0160-3. Epub 2017 Feb 16.

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model.体外诱导人星形胶质细胞和帕金森病模型中小鼠星形胶质细胞产生功能性多巴胺神经元。

Nat Biotechnol. 2017 May;35(5):444-452. doi: 10.1038/nbt.3835. Epub 2017 Apr 10.

Effects of Rho Kinase Inhibitors on Grafts of Dopaminergic Cell Precursors in a Rat Model of Parkinson's Disease.Rho激酶抑制剂对帕金森病大鼠模型中多巴胺能细胞前体移植的影响

Stem Cells Transl Med. 2016 Jun;5(6):804-15. doi: 10.5966/sctm.2015-0182. Epub 2016 Apr 13.

Targeting 5-HT(1A) receptors in astrocytes to protect dopaminergic neurons in Parkinsonian models.靶向星形胶质细胞 5-HT(1A)受体以保护帕金森病模型中的多巴胺能神经元。

Neurobiol Dis. 2013 Nov;59:244-56. doi: 10.1016/j.nbd.2013.08.003. Epub 2013 Aug 17.

Aquaporin-4 deficiency diminishes the differential degeneration of midbrain dopaminergic neurons in experimental Parkinson's disease.水通道蛋白4缺乏可减轻实验性帕金森病中脑多巴胺能神经元的差异性退变。

Neurosci Lett. 2016 Feb 12;614:7-15. doi: 10.1016/j.neulet.2015.12.057. Epub 2015 Dec 31.

MicroRNA alterations in iPSC-derived dopaminergic neurons from Parkinson disease patients.帕金森病患者诱导多能干细胞衍生的多巴胺能神经元中的 microRNA 改变。

Neurobiol Aging. 2018 Sep;69:283-291. doi: 10.1016/j.neurobiolaging.2018.05.032. Epub 2018 May 31.

Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson's disease.区域小胶质细胞在转录上是不同的，但在帕金森病的培养模型中同样加剧神经退行性变。

J Neuroinflammation. 2018 May 11;15(1):139. doi: 10.1186/s12974-018-1181-x.

Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA.星形胶质细胞功能障碍持续时间延长和小胶质细胞激活加速了大鼠黑质多巴胺能神经元的变性，并阻断了 6-OHDA 诱导的早期运动功能障碍的代偿。

Mol Neurobiol. 2018 Apr;55(4):3049-3066. doi: 10.1007/s12035-017-0529-z. Epub 2017 May 2.

引用本文的文献

Direct Conversion of Astrocytes to Neurons Maybe a Potential Alternative Strategy for Neurodegenerative Diseases.将星形胶质细胞直接转化为神经元可能是神经退行性疾病的一种潜在替代策略。

Front Aging Neurosci. 2021 Aug 2;13:689276. doi: 10.3389/fnagi.2021.689276. eCollection 2021.

Commentary: Neuroregeneration to Treat Ischemic Stroke Through NeuroD1 AAV-Based Gene Therapy in Adult Non-human Primates.评论：通过基于NeuroD1腺相关病毒的基因疗法在成年非人类灵长类动物中进行神经再生以治疗缺血性中风。

Front Cell Dev Biol. 2021 May 28;9:648020. doi: 10.3389/fcell.2021.648020. eCollection 2021.

Gut Microbiota Regulate Astrocytic Functions in the Brain: Possible Therapeutic Consequences.肠道微生物群调控大脑中的星形胶质细胞功能：可能的治疗后果。

Curr Neuropharmacol. 2021;19(8):1354-1366. doi: 10.2174/1570159X19666210215123239.

Advances in Transcription Factors Related to Neuroglial Cell Reprogramming.与神经胶质细胞重编程相关的转录因子研究进展

Transl Neurosci. 2020 Feb 20;11:17-27. doi: 10.1515/tnsci-2020-0004. eCollection 2020.

本文引用的文献

Nat Biotechnol. 2017 May;35(5):444-452. doi: 10.1038/nbt.3835. Epub 2017 Apr 10.

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