Liu Kuangpin, Ma Wei, Li Chunyan, Li Junjun, Zhang Xingkui, Liu Jie, Liu Wei, Wu Zheng, Zang Chenghao, Liang Yu, Guo Jianhui, Li Liyan
Institute of Neuroscience, Kunming Medical University, Kunming, Yunnan, China.
Second Department of General Surgery, First People's Hospital of Yunnan Province, Kunming, Yunnan, China.
Transl Neurosci. 2020 Feb 20;11:17-27. doi: 10.1515/tnsci-2020-0004. eCollection 2020.
Neuroglial cells have a high level of plasticity, and many types of these cells are present in the nervous system. Neuroglial cells provide diverse therapeutic targets for neurological diseases and injury repair. Cell reprogramming technology provides an efficient pathway for cell transformation during neural regeneration, while transcription factor-mediated reprogramming can facilitate the understanding of how neuroglial cells mature into functional neurons and promote neurological function recovery.
神经胶质细胞具有高度的可塑性，神经系统中存在多种这类细胞。神经胶质细胞为神经疾病和损伤修复提供了多样的治疗靶点。细胞重编程技术为神经再生过程中的细胞转化提供了一条有效途径，而转录因子介导的重编程有助于理解神经胶质细胞如何成熟为功能性神经元并促进神经功能恢复。
