Salgado-Bernabé Aralia Berenice, Ramos-Arellanol Luz Elena, Guzmán-Guzmán Iris Paola, Muñoz-Valle José Francisco, Castro-Alarcón Natividad, Vences-Velázquez Amalia, Salga-do-Goytia Lorenzo, Parra-Rojas Isela
Invest Clin. 2016 Jun;57(2):120-130.
Obesity is associated with a state of chronic low-grade inflammation. Ge- nerally, there are significant correlations between body mass index and increased C-reactive protein levels. We investigated the relationship of high sensitivity C-reactive protein (hsCRP) levels with body adiposity distribution and blood cell count in obese children. A cross-sec- tional study was performed in 225 Mexican children. In the study were included 106 obese and 119 normal-weight children, aged 6-13 years old. The body composition was evaluated by BMI, body circumferences and skinfold thickness. hsCRP levels and hematological para- meters were analyzed in all children. The hsCRP levels were higher in obese children than in the control group (1.5 and 0.41 mg/L respectively, P<0.001). Interestingly, hsCRP levels >3 mg/L were associated with the increase of circumferences of the waist, hip and arms (ORs= 9.08, 6.78 and 8.73, respectively, P<0.001), and,a higher thickness of triceps, subscapular and suprailiac skinfolds (ORs= 4.73, 6.39 and 5.26, respectively, P=0.001), as well as a higher leukocyte and platelet counts. The data suggest that hsCRP levels are associated with skinfold thickness and body circumferences, and a moderate relationship was found with leukocyte and Dlatelet counts in the studied children.
肥胖与慢性低度炎症状态相关。一般来说，体重指数与C反应蛋白水平升高之间存在显著相关性。我们研究了肥胖儿童中高敏C反应蛋白（hsCRP）水平与身体脂肪分布及血细胞计数之间的关系。对225名墨西哥儿童进行了一项横断面研究。该研究纳入了106名肥胖儿童和119名体重正常的儿童，年龄在6至13岁之间。通过体重指数、身体周长和皮褶厚度评估身体成分。对所有儿童的hsCRP水平和血液学参数进行了分析。肥胖儿童的hsCRP水平高于对照组（分别为1.5和0.41mg/L，P<0.001）。有趣的是，hsCRP水平>3mg/L与腰围、臀围和臂围增加相关（OR分别为9.08、6.78和8.73，P<0.001），以及肱三头肌、肩胛下和髂上皮肤褶皱厚度增加相关（OR分别为4.73、6.39和5.26，P=0.001），同时白细胞和血小板计数也更高。数据表明，在研究的儿童中，hsCRP水平与皮褶厚度和身体周长相关，并且与白细胞和血小板计数存在中等程度的关系。
