Yang Liying, Zhang Wei
Department of Neonatal Intensive Care Unit, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Department of Neonatal Intensive Care Unit, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. Email:
Asia Pac J Clin Nutr. 2017 May;26(3):427-433. doi: 10.6133/apjcn.042016.01.
This study aimed to evaluate the relationship between serum 25-hydroxy-vitamin D and bone metabolism in healthy women of reproductive age.
This study included 100 healthy female residents of Beijing (23-30 years old), who underwent bone ultrasonography as well as testing to evaluate serum25-hydroxy-vitamin D, parathyroid hormone, bone alkaline phosphatase, calcium, sodium, phosphorus, and alkaline phosphatase.
Mean 25-hydroxy-vitamin D in the winter (22.3±3.55 nmol/L) was significantly lower than that in the summer (46.2±16.3 nmol/L). In the winter, a negative correlation was observed between 25-hydroxy-vitamin D and parathyroid hormone(r=0.300, p=0.002) and bone alkaline phosphatase (r=0.274, p=0.016). In the summer, a negative correlation was observed between 25-hydroxy-vitamin D and parathyroid hormone (r=0.386, p<0.001) and bone alkaline phosphatase (r=0.523, p<0.001). Serum calcium, sodium, phosphorus, and alkaline phosphatase were within the normal ranges for both winter and summer, and exhibited no significant correlations with serum 25-hydroxy-vitamin D. The mean speed of sound during bone ultrasonography was 4,125±365 m/s, and a linear correlation was observed between 25-hydroxy-vitamin D and the speed of sound (r=0.215, p=0.031). Serum alkaline phosphatise was not correlated with bone alkaline phosphatase.
Serum vitamin D deficiency was common among healthy women of childbearing age in Beijing during both winter and summer. Furthermore, bone ultrasonography findings and serum vitamin D, parathyroid hormone, and bone alkaline phosphatase accurately reflected these women's bone metabolism status.
本研究旨在评估育龄健康女性血清25-羟维生素D与骨代谢之间的关系。
本研究纳入了100名北京地区年龄在23至30岁的健康女性居民，她们接受了骨超声检查以及血清25-羟维生素D、甲状旁腺激素、骨碱性磷酸酶、钙、钠、磷和碱性磷酸酶的检测。
冬季25-羟维生素D的平均水平（22.3±3.55 nmol/L）显著低于夏季（46.2±16.3 nmol/L）。在冬季，25-羟维生素D与甲状旁腺激素（r=0.300，p=0.002）以及骨碱性磷酸酶（r=0.274，p=0.016）之间呈负相关。在夏季，25-羟维生素D与甲状旁腺激素（r=0.386，p<0.001）以及骨碱性磷酸酶（r=0.523，p<0.001）之间呈负相关。血清钙、钠、磷和碱性磷酸酶在冬季和夏季均处于正常范围内，且与血清25-羟维生素D无显著相关性。骨超声检查的平均声速为4125±365 m/s，25-羟维生素D与声速之间呈线性相关（r=0.215，p=0.031）。血清碱性磷酸酶与骨碱性磷酸酶无相关性。
北京育龄健康女性在冬季和夏季均普遍存在血清维生素D缺乏的情况。此外，骨超声检查结果以及血清维生素D、甲状旁腺激素和骨碱性磷酸酶准确反映了这些女性的骨代谢状况。
