Schmiester Maren, Demuth Ilja
Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
Oncotarget. 2017 Jul 18;8(29):48398-48409. doi: 10.18632/oncotarget.16864.
hSNM1B/Apollo is a member of the highly conserved β-CASP subgroup within the MBL superfamily of proteins. It interacts with several DNA repair proteins and functions within the Fanconi anemia pathway in response to DNA interstrand crosslinks. As a shelterin accessory protein, hSNM1B/Apollo is also vital for the generation and maintenance of telomeric overhangs. In this review, we will summarize studies on hSNM1B/Apollo's function, including its contribution to DNA damage signaling, replication fork maintenance, control of topological stress and telomere protection. Furthermore, we will highlight recent studies illustrating hSNM1B/Apollo's putative role in human disease.
hSNM1B/Apollo是蛋白质MBL超家族中高度保守的β-CASP亚组的成员。它与多种DNA修复蛋白相互作用，并在范可尼贫血途径中发挥作用以应对DNA链间交联。作为一种端粒保护蛋白，hSNM1B/Apollo对于端粒悬突的产生和维持也至关重要。在这篇综述中，我们将总结关于hSNM1B/Apollo功能的研究，包括其在DNA损伤信号传导、复制叉维持、拓扑应力控制和端粒保护中的作用。此外，我们将重点介绍最近说明hSNM1B/Apollo在人类疾病中假定作用的研究。
