复制应激：重回正轨。
Replication stress: getting back on track.
作者信息
Berti Matteo, Vindigni Alessandro
出版信息
Nat Struct Mol Biol. 2016 Feb;23(2):103-9. doi: 10.1038/nsmb.3163.
Abstract
The replication-stress response enables the DNA replication machinery to overcome DNA lesions or intrinsic replication-fork obstacles, and it is essential to ensure faithful transmission of genetic information to daughter cells. Multiple replication stress–response pathways have been identified in recent years, thus raising questions about the specific and possibly redundant functions of these pathways. Here, we review the emerging mechanisms of the replication-stress response in mammalian cells and consider how they may influence the dynamics of the core DNA replication complex.
摘要
复制应激反应使DNA复制机制能够克服DNA损伤或内在的复制叉障碍，对于确保遗传信息准确传递给子细胞至关重要。近年来已鉴定出多种复制应激反应途径，这就引发了关于这些途径的特定功能以及可能存在的冗余功能的问题。在这里，我们综述了哺乳动物细胞中复制应激反应的新出现机制，并探讨它们如何影响核心DNA复制复合体的动态变化。
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