Chen Y, Zhou J L, Cheng L, Zheng Y Y, Xu J
State Key Laboratory of Estuarine and Coastal Research, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China.
State Key Laboratory of Estuarine and Coastal Research, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China.
Chemosphere. 2017 Aug;180:467-475. doi: 10.1016/j.chemosphere.2017.04.055. Epub 2017 Apr 14.
The dynamic distribution of a widely used antibiotic sulfamethoxazole between water, sediment and aquatic organisms (zebrafish) was studied in microcosms. Sulfamethoxazole concentrations in water were gradually reduced, while in sediment and zebrafish gradually increased, suggesting active adsorption and bioaccumulation processes occurring. The presence of sediment particles and their interactions with water reduced the bioaccumulation of sulfamethoxazole in zebrafish by 13-28%. The sediment of smaller particle size with more organic carbon content and higher surface area, adsorbed sulfamethoxazole more extensively and decreased its bioaccumulation most significantly. The effect became more severe with increasing salinity in water due to the salting out of sulfamethoxazole, resulting in 24-33% reduction in bioaccumulation. At equilibrium, the distribution of sulfamethoxazole in different phases was quantified, with most sulfamethoxazole being associated with water (97.3%), followed by sedimentary phase (2.7%) and finally zebrafish (0.05%). The findings provided important data for further research into antibiotics fate and bio-uptake in aquatic organisms, and subsequent ecotoxicity.
在微观世界中研究了一种广泛使用的抗生素磺胺甲恶唑在水、沉积物和水生生物（斑马鱼）之间的动态分布。水中磺胺甲恶唑的浓度逐渐降低，而在沉积物和斑马鱼中则逐渐升高，这表明存在活跃的吸附和生物累积过程。沉积物颗粒的存在及其与水的相互作用使磺胺甲恶唑在斑马鱼中的生物累积减少了13%-28%。粒径较小、有机碳含量较高且表面积较大的沉积物对磺胺甲恶唑的吸附更广泛，并且最显著地降低了其生物累积。由于磺胺甲恶唑的盐析作用，随着水中盐度的增加，这种影响变得更加严重，导致生物累积减少24%-33%。在平衡状态下，对磺胺甲恶唑在不同相中的分布进行了量化，大部分磺胺甲恶唑与水相关（97.3%），其次是沉积相（2.7%），最后是斑马鱼（0.05%）。这些发现为进一步研究抗生素在水生生物中的归宿和生物摄取以及随后的生态毒性提供了重要数据。
