Miró María Soledad, Rodríguez Emilse, Vigezzi Cecilia, Icely Paula Alejandra, Gonzaga de Freitas Araújo Marcelo, Riera Fernando Oscar, Vargas Lara, Abiega Claudio, Caeiro Juan Pablo, Sotomayor Claudia Elena
Laboratorio de Inmunidad Innata a Patógenos Fúngicos, Departamento de Bioquímica Clínica, Centro de Investigaciones en Bioquímica Clínica e Inmunología, CIBICI-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Research Group of Immunology and Mycology.
Laboratorio de Inmunidad Innata a Patógenos Fúngicos, Departamento de Bioquímica Clínica, Centro de Investigaciones en Bioquímica Clínica e Inmunología, CIBICI-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Rev Iberoam Micol. 2017 Apr-Jun;34(2):65-71. doi: 10.1016/j.riam.2016.11.006. Epub 2017 Apr 18.
Vulvovaginal candidiasis is an old disease that, even in a modern world, continues to have a high incidence. Despite the therapeutic advances, treatments are not always effective, and our understanding of the pathogenesis of this fungal infection is still incomplete. A discussion is presented in this article on the most significant developments related to the fungal virulence factors, the role of the immunological mechanisms involved in the vaginal protection, and the genetic alterations that confer susceptibility to the recurrent form of this mycosis. Current treatments, the use of new agents with antifungal activity, as well as the development of strategies, such as vaccination, are approached in the context of the complex scenario that governs the interactions between Candida and its host.
外阴阴道念珠菌病是一种古老的疾病，即便在现代社会，其发病率仍居高不下。尽管治疗方面取得了进展，但治疗并非总是有效，而且我们对这种真菌感染的发病机制的理解仍不完整。本文讨论了与真菌毒力因子、参与阴道保护的免疫机制的作用以及导致这种真菌病复发形式易感性的基因改变相关的最重要进展。在念珠菌与其宿主之间相互作用的复杂背景下，探讨了当前的治疗方法、具有抗真菌活性的新药物的使用以及诸如疫苗接种等策略的开发。
