凝溶胶蛋白是血小板中肌动球蛋白系统的钙敏感性调节因子。

Gelsolin is Ca2+-sensitive regulator of actomyosin system in platelet.

作者信息

Onji T, Takagi M, Shibata N

机构信息

Division of Molecular Cardiology, Center for Adult Diseases, Osaka, Japan.

出版信息

Biochem Biophys Res Commun. 1988 Aug 30;155(1):91-9. doi: 10.1016/s0006-291x(88)81053-2.

DOI:10.1016/s0006-291x(88)81053-2

PMID:2843191

Abstract

Effects of gelsolin on the actomyosin system in platelet have been studied. MgATPase activity of platelet actomyosin is enhanced up to two folds by 200 nM of platelet gelsolin in the presence, but not in the absence of Ca ion. The half maximum enhancement is observed at the concentration of Ca2+ around 10(-5) M. The effect of gelsolin to enhance the ATPase activity of actomyosin is potentiated by tropomyosin, which is a Ca2+-insensitive actomyosin enhancer. The results indicate that gelsolin may control the activity of actomyosin system in platelets.

摘要

已经研究了凝溶胶蛋白对血小板中肌动球蛋白系统的影响。在有钙离子存在而不是没有钙离子存在的情况下，200 nM的血小板凝溶胶蛋白可使血小板肌动球蛋白的MgATP酶活性增强两倍。在Ca2+浓度约为10(-5) M时观察到最大增强效果的一半。原肌球蛋白可增强凝溶胶蛋白对肌动球蛋白ATP酶活性的增强作用，原肌球蛋白是一种对Ca2+不敏感的肌动球蛋白增强剂。结果表明，凝溶胶蛋白可能控制血小板中肌动球蛋白系统的活性。