ADP和凝血酶刺激的血小板的细胞骨架。在刺激的不同阶段存在一种类钙调蛋白、α-辅肌动蛋白和凝溶胶蛋白。

Cytoskeletons of ADP- and thrombin-stimulated blood platelets. Presence of a caldesmon-like protein, alpha-actinin and gelsolin at different steps of the stimulation.

作者信息

Pho D B, Desbruyères E, Der Terrossian E, Olomucki A

出版信息

FEBS Lett. 1986 Jun 23;202(1):117-21. doi: 10.1016/0014-5793(86)80660-3.

Abstract

Comparative analyses of the cytoskeletons of resting and stimulated platelets point out the involvement of a 79 kDa polypeptide in the activation step and its increased incorporation during aggregation. It appears as a doublet and cross-reacts with an antibody to chicken gizzard caldesmon, whereas no 150 kDa immunoreactive form was detected. alpha-Actinin and gelsolin were detected only in the aggregation step.

摘要

对静息血小板和激活血小板的细胞骨架进行的比较分析表明，一种79 kDa的多肽参与了激活过程，并且在聚集过程中其掺入量增加。它表现为一条双条带，并与抗鸡砂囊钙调蛋白的抗体发生交叉反应，而未检测到150 kDa的免疫反应形式。仅在聚集过程中检测到α-辅肌动蛋白和凝溶胶蛋白。