Zachariah P K, Sheps S G, Schwartz G L, Schirger A, Ilstrup D M, Long C R, Carlson C A
Division of Hypertension and Internal Medicine, Mayo Clinic, Rochester, MN 55905.
Am J Hypertens. 1988 Jul;1(3 Pt 3):274S-279S. doi: 10.1093/ajh/1.3.274s.
Noninvasive automatic ambulatory blood pressure monitoring during 24 hours in eight patients with moderate hypertension was used to determine the blood pressure response to lisinopril, an angiotensin-converting enzyme inhibitor. Office, 24-hour ambulatory, awake ambulatory, and sleep ambulatory diastolic blood pressures were decreased from 108 +/- 3, 98 +/- 8, 101 +/- 7, and 87 +/- 14 mm Hg, respectively, at baseline to 83 +/- 4 (P less than or equal to 0.0001), 82 +/- 7 (P less than 0.0001), 84 +/- 7 (P less than 0.0001), and 73 +/- 9 mm Hg (P less than 0.005), respectively, after 20 weeks of lisinopril treatment (dose range, 40 to 80 mg once daily). The diastolic blood pressure loads (percentages of ambulatory diastolic blood pressures more than 90 mm Hg) during 24 hours and during awake hours were 74% +/- 19% and 83% +/- 15%, respectively, at baseline and 24% +/- 19% (P less than 0.0001) and 29% +/- 21% (P less than 0.0001), respectively, during treatment. Heart rate was not altered by lisinopril. In conclusion, lisinopril is an effective antihypertensive agent for the treatment of moderate hypertension, and ambulatory blood pressures and diastolic blood pressure loads are useful for evaluating therapy for hypertension.
对8例中度高血压患者进行了24小时无创动态血压监测，以确定血管紧张素转换酶抑制剂赖诺普利的血压反应。基线时，诊室、24小时动态、清醒时动态及睡眠时动态舒张压分别为108±3、98±8、101±7和87±14 mmHg，赖诺普利治疗20周后（剂量范围为每日40至80 mg），分别降至83±4（P≤0.0001）、82±7（P＜0.0001）、84±7（P＜0.0001）和73±9 mmHg（P＜0.005）。治疗期间，24小时及清醒时的舒张压负荷（动态舒张压超过90 mmHg的百分比）在基线时分别为74%±19%和83%±15%，治疗期间分别为24%±19%（P＜0.0001）和29%±21%（P＜0.0001）。赖诺普利未改变心率。总之，赖诺普利是治疗中度高血压的有效抗高血压药物，动态血压及舒张压负荷对评估高血压治疗有效。
