Wang Haiyong, Zhang Jingze, Shi Fang, Zhang Chenyue, Jiao Qinghua, Zhu Hui
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan 250117, China.
Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Oncotarget. 2017 May 23;8(21):34923-34934. doi: 10.18632/oncotarget.16823.
It has been reported that younger patients with non-small cell lung cancer (NSCLC) tend to have a better prognosis. Yet, few studies have focused on the clinicopathological characteristics and prognosis of young small cell lung cancer (SCLC), especially for patients with age < 50. In our study, we used Surveillance, Epidemiology, and End Results (SEER) population-based data and identified 16503 patients with SCLC including 711 patients aged < 50, 3338 patients aged 50-59, 5937 patients aged 60-69, 4649 patients aged 70-79 and 1868 patients aged ≥ 80 between 2010 and 2013. The Kaplan-Meier methods was used to develop the survival curve, and the results showed that the SCLC patients with aged < 50 tended to a better over survival (OS) and cancer specific survival (CSS) (all, P < 0.001). In addition, Cox regression model was used to analyze survival prognosis factors and perform subgroup analysis. The results showed that age was an independent prognostic factor for CSS (P < 0.001). Importantly, we found that for the patients with AJCC stage III subgroup, the age < 50 had apparent CSS benefit compared with any other age group (all, P < 0.01). Interestingly, for the patients with no surgery, radiation and no radiation subgroup, the age < 50 had no apparent CSS benefit only compared with age 50-59 (all, P > 0.05). In conclusion, our study demonstrated that the SCLC patients with aged < 50 tended had a better survival benefit, especially for patients with AJCC stage III.
据报道,非小细胞肺癌(NSCLC)的年轻患者往往预后较好。然而,很少有研究关注年轻小细胞肺癌(SCLC)的临床病理特征和预后,尤其是年龄<50岁的患者。在我们的研究中,我们使用了基于监测、流行病学和最终结果(SEER)的人群数据,确定了16503例SCLC患者,其中包括2010年至2013年间711例年龄<50岁、3338例年龄在50-59岁、5937例年龄在60-69岁、4649例年龄在70-79岁和1868例年龄≥80岁的患者。采用Kaplan-Meier方法绘制生存曲线,结果显示年龄<50岁的SCLC患者总生存期(OS)和癌症特异性生存期(CSS)往往更好(均P<0.001)。此外,使用Cox回归模型分析生存预后因素并进行亚组分析。结果显示年龄是CSS的独立预后因素(P<0.001)。重要的是,我们发现对于美国癌症联合委员会(AJCC)III期亚组的患者,年龄<50岁与其他任何年龄组相比具有明显的CSS获益(均P<0.01)。有趣的是,对于未进行手术、放疗和未进行放疗亚组的患者,年龄<50岁仅与年龄在50-59岁的患者相比没有明显的CSS获益(均P>0.05)。总之,我们的研究表明年龄<50岁的SCLC患者往往具有更好的生存获益,尤其是对于AJCC III期的患者。