Lin Pei-Yun, Wang Peng-Wei, Chen Cheng-Sheng, Yen Cheng-Fang
Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Psychiatry, School of Medicine, and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Psychiatry, School of Medicine, and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2017 May;33(5):260-265. doi: 10.1016/j.kjms.2017.02.004. Epub 2017 Mar 15.
This study compared the levels of the five domains of neurocognitive function-executive function, attention, memory, verbal comprehension, and perceptual organization-among clinically stable individuals with long-term bipolar I disorder, individuals with long-term schizophrenia, and a group of controls. We recruited a total of 93 clinically stable individuals with bipolar I disorder, 94 individuals with schizophrenia, and 106 controls in this study. Their neurocognitive function was measured using a series of neurocognitive function tests: the Wechsler Adult Intelligence Scale-Third Edition (WAIS-III), Line Cancellation Test, Visual Form Discrimination, Controlled Oral Word Association Test, Wisconsin Card Sorting Test, Continuous Performance Task, and Wechsler Memory Scale-Third Edition. Neurocognitive function was compared among the three groups through a multivariate analysis of variance. The results indicated that when the effect of age was controlled, clinically stable individuals with bipolar I disorder and those with schizophrenia demonstrated poor neurocognitive function on all tests except for the WAIS-III Similarity and Information and the Line Cancellation Test. The individuals with bipolar I disorder had similar levels of neurocognitive function compared with the schizophrenia group, but higher levels of neurocognitive function on the WAIS-III Comprehension, Controlled Oral Word Association Test, and Wechsler Memory Scale-Third Edition Auditory Immediate and Delayed Index and Visual Immediate and Delayed Index. The conclusions of this study suggest that compared with controls, individuals with long-term bipolar I disorder and those with long-term schizophrenia have poorer neurocognitive function, even when clinically stable. Individuals with long-term bipolar I disorder and those with long-term schizophrenia have similar levels of deficits in several domains of neurocognitive function.
本研究比较了临床症状稳定的长期双相I型障碍患者、长期精神分裂症患者以及一组对照人群在神经认知功能五个领域（执行功能、注意力、记忆、语言理解和知觉组织）的水平。在本研究中，我们共招募了93名临床症状稳定的双相I型障碍患者、94名精神分裂症患者和106名对照者。使用一系列神经认知功能测试对他们的神经认知功能进行测量：韦氏成人智力量表第三版（WAIS-III）、划消测验、视觉形状辨别、受控口语联想测验、威斯康星卡片分类测验、持续性操作任务以及韦氏记忆量表第三版。通过多因素方差分析对三组之间的神经认知功能进行比较。结果表明，在控制年龄影响后，临床症状稳定的双相I型障碍患者和精神分裂症患者在除WAIS-III相似性和知识分测验以及划消测验之外的所有测试中均表现出较差的神经认知功能。双相I型障碍患者与精神分裂症组的神经认知功能水平相似，但在WAIS-III领悟分测验、受控口语联想测验以及韦氏记忆量表第三版听觉即刻和延迟指数以及视觉即刻和延迟指数方面具有更高的神经认知功能水平。本研究的结论表明，与对照者相比，即使临床症状稳定，长期双相I型障碍患者和长期精神分裂症患者的神经认知功能也较差。长期双相I型障碍患者和长期精神分裂症患者在神经认知功能的几个领域中存在相似程度的缺陷。
