Trivedi J K, Goel Dishanter, Sharma Sachin, Singh A P, Sinha P K, Tandon Rajul
Department of Psychiatry, King George's Medical University, Lucknow, India.
Indian J Med Res. 2007 Nov;126(5):433-9.
BACKGROUND & OBJECTIVES: Some cognitive deficits in schizophrenia and bipolar disorders persist after the subsidence of active symptoms. We carried out this study to assess and compare the cognitive functioning of patients with stable schizophrenia and bipolar disorder.
Fifteen each of stable maintained schizophrenic patients and euthymic bipolar-I patients attending outpatient clinic in a tertiary care psychiatric hospital in north India were included in the study as also equal number of age and education matched control subjects. Cognitive assessments were done using Wisconsin's Card Sorting Test (WCST), Spatial Working Memory Test (SWMT) and Continuous Performance Test (CPT).
Stable schizophrenia patients performed poorly on all the neurocognitive parameters as compared to both controls and bipolar euthymic patients. Euthymic bipolar patients showed significant difference on executive functions with normal controls. Patterns of cognitive disturbances in tasks of executive function are similar in both groups but are quantitatively more marked in schizophrenia.
INTERPRETATION & CONCLUSIONS: Our results showed that stable schizophrenia patients performed significantly worse on cognitive measures than patients of euthymic bipolar disorder which was consistent with their poorer functional outcome. The results further indicated that stable schizophrenia and euthymic bipolar disorders may be distinguished qualitatively in neuropsychological terms with different profiles of cognitive impairment.
精神分裂症和双相情感障碍的一些认知缺陷在活动症状消退后仍会持续。我们开展本研究以评估和比较稳定期精神分裂症患者和双相情感障碍患者的认知功能。
印度北部一家三级护理精神病院门诊的15例稳定期精神分裂症维持治疗患者和15例心境正常的双相I型障碍患者被纳入研究，同时纳入了同等数量的年龄和教育程度匹配的对照受试者。使用威斯康星卡片分类测验（WCST）、空间工作记忆测验（SWMT）和持续性操作测验（CPT）进行认知评估。
与对照组和双相情感障碍心境正常患者相比，稳定期精神分裂症患者在所有神经认知参数上表现较差。心境正常的双相情感障碍患者与正常对照组相比，在执行功能方面存在显著差异。两组执行功能任务中的认知障碍模式相似，但在精神分裂症中在数量上更为明显。
我们的结果表明，稳定期精神分裂症患者在认知测量方面的表现明显比心境正常的双相情感障碍患者差，这与其较差的功能结局一致。结果进一步表明，稳定期精神分裂症和心境正常的双相情感障碍在神经心理学方面可能在认知损害的不同特征上存在质的区别。
