Huang Z Y, Li H Z, Xu P Q
Beijing Tuberculosis and Pulmonary Tumor Institute.
Zhonghua Zhong Liu Za Zhi. 1988 Jan;10(1):38-41.
This paper presents the pathological findings of small cell carcinoma of lung of 202 patients treated by surgery in our department from 1957 to 1984. Small cell lung cancer comprises 15.7% of all lung cancers. Gross type: central type was 67.3% and peripheral type was 32.7%. According to the histological classification system for lung tumor, WHO, 1981, small cell carcinoma is divided into three subtypes: (1) oat cell carcinoma (118 cases), (2) intermediate cell type (55 cases), and (3) mixed oat cell carcinoma (29 cases). Electronic microscope examination was done in 3 cases. Neurogenic secretory bodies in the cytoplasm were found in 2 oat cell carcinoma, but not in the other intermediate cell type. The 5-year survival rate of small cell carcinoma was 22.4% among whom four survived over ten years. The 5-year survival rate of oat cell carcinoma, intermediate cell type and mixed oat cell carcinoma were 19%, 34.8% and 9.1%, respectively. The intermediate cell type was the best in the 3 types. The 5-year survival rate of the peripheral type was 30.4% which was higher than that of the central type (18.9%). The 5-year survival rate was 30.8% in patients without metastasis to the lymph nodes in the hilus or mediastinum, and 18% in those with metastasis. There were no differences in the prognosis of those whether the pleura were involved or the resection stump was positive.
本文介绍了1957年至1984年在我科接受手术治疗的202例肺小细胞癌患者的病理检查结果。肺小细胞癌占所有肺癌的15.7%。大体类型：中央型占67.3%，周围型占32.7%。根据1981年世界卫生组织的肺肿瘤组织学分类系统，小细胞癌分为三个亚型：（1）燕麦细胞癌（118例），（2）中间细胞型（55例），（3）混合燕麦细胞癌（29例）。对3例进行了电子显微镜检查。在2例燕麦细胞癌的细胞质中发现了神经分泌小体，而在其他中间细胞型中未发现。小细胞癌的5年生存率为22.4%，其中4例存活超过10年。燕麦细胞癌、中间细胞型和混合燕麦细胞癌的5年生存率分别为19%、34.8%和9.1%。中间细胞型在这三种类型中预后最好。周围型的5年生存率为30.4%，高于中央型（18.9%）。肺门或纵隔淋巴结无转移患者的5年生存率为30.8%，有转移患者的5年生存率为18%。胸膜是否受累或切除残端是否阳性对预后无差异。
