De Rose F, Franceschini D, Reggiori G, Stravato A, Navarria P, Ascolese A M, Tomatis S, Mancosu P, Scorsetti M
Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy.
Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy.
Phys Med. 2017 Dec;44:131-138. doi: 10.1016/j.ejmp.2017.04.010. Epub 2017 Apr 19.
Lung stereotactic body radiotherapy (SBRT) is an accurate and precise technique to treat lung tumors with high 'ablative' doses. Given the encouraging data in terms of local control and toxicity profile, SBRT has currently become a treatment option for both early stage lung cancer and lung oligometastatic disease in patients who are medically inoperable or refuse surgical resection. Dose-adapted fractionation schedules and ongoing prospective trials should provide further evidence of SBRT safety trying to reduce toxicities and complications. In this heterogeneous scenario, a non-systematic review of dose constraints for lung SBRT was performed, including the main organs at risk in the thorax.
肺部立体定向体部放疗(SBRT)是一种使用高“消融”剂量治疗肺部肿瘤的精确技术。鉴于在局部控制和毒性方面的数据令人鼓舞,SBRT目前已成为医学上无法手术或拒绝手术切除的早期肺癌和肺寡转移疾病患者的一种治疗选择。剂量适应性分割方案和正在进行的前瞻性试验应能提供更多关于SBRT安全性的证据,以试图降低毒性和并发症。在这种复杂的情况下,我们对肺部SBRT的剂量限制进行了非系统性综述,包括胸部的主要危及器官。