Institute for Medical Immunology, Université Libre de Bruxelles, Brussels, Belgium.
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Division of Infectious Diseases, Department of Pediatrics, University of British Columbia and BC Children's Hospital, Vancouver, BC, Canada; Vaccine Evaluation Center, University of British Columbia and BC Children's Hospital, Vancouver, BC, Canada.
Lancet Infect Dis. 2017 Jul;17(7):e197-e208. doi: 10.1016/S1473-3099(17)30229-3. Epub 2017 Apr 19.
Maternal immunisation has the potential to substantially reduce morbidity and mortality from infectious diseases after birth. The success of tetanus, influenza, and pertussis immunisation during pregnancy has led to consideration of additional maternal immunisation strategies to prevent group B streptococcus and respiratory syncytial virus infections, among others. However, many gaps in knowledge regarding the immunobiology of maternal immunisation prevent the optimal design and application of this successful public health intervention. Therefore, we did an innovative landscape analysis to identify research priorities. Key topics were delineated through review of the published literature, consultation with vaccine developers and regulatory agencies, and a collaborative workshop that gathered experts across several maternal immunisation initiatives-group B streptococcus, respiratory syncytial virus, pertussis, and influenza. Finally, a global online survey prioritised the identified knowledge gaps on the basis of expert opinion about their importance and relevance. Here we present the results of this worldwide landscape analysis and discuss the identified research gaps.
母体免疫接种有可能显著降低出生后传染病的发病率和死亡率。破伤风、流感和百日咳疫苗在妊娠期间的成功接种，促使人们考虑采取其他母体免疫接种策略，以预防 B 组链球菌和呼吸道合胞病毒感染等。然而，母体免疫接种的免疫生物学方面存在许多知识空白，阻碍了这一成功的公共卫生干预措施的最佳设计和应用。因此，我们进行了一项创新性的全景分析，以确定研究重点。通过对已发表文献的回顾、与疫苗开发商和监管机构的磋商，以及汇集了多个母体免疫计划（B 组链球菌、呼吸道合胞病毒、百日咳和流感）专家的协作研讨会，确定了关键主题。最后，一项全球在线调查根据专家对其重要性和相关性的看法，对已确定的知识空白进行了优先级排序。在这里，我们展示了这项全球性全景分析的结果，并讨论了所确定的研究空白。
