Sarna Mohinder, Taye Belaynew, Le Huong, Giannini Fiona, Glass Kathryn, Blyth Christopher C, Richmond Peter, Glauert Rebecca, Levy Avram, Moore Hannah C
Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia.
School of Population Health, Curtin University, Bentley, WA, Australia.
Int J Popul Data Sci. 2024 Apr 11;9(2):2376. doi: 10.23889/ijpds.v9i2.2376. eCollection 2024.
The Western Australia (WA) Respiratory Infections Linked Data Platform is a population-based cohort established to investigate the epidemiology of RSV and other respiratory infections in children aged 0-10 years, incorporating microbiological testing patterns, hospital admissions, emergency department presentations, and socio-demographic data.
The cohort was formed through individual linkages between datasets from the WA Department of Health including the Birth and Death Registry, Midwives Notification System (MNS), Hospital Morbidity Data Collection, Emergency Department Data Collection, WA Notifiable Diseases Database, WA Register of Developmental Anomalies, WA Cerebral Palsy Register, WA Antenatal Vaccination Database, WA Family Connections, and PathWest Respiratory Virus Surveillance Data. Hospitalisations and emergency department presentations were temporally linked to routine respiratory viral surveillance data.
The cohort consists of 368,830 WA births between 1 January 2010 and 31 December 2020 with accompanying perinatal and demographic data, and with secondary care follow-up to 30 June 2022. Of these births, 24,660 (6.7%) identify as Aboriginal. A total of 4,077 (1.1%) children died from all causes during the study period (2010-2020), and 9.2% (33,818) of children were born preterm (<37 weeks).
The Respiratory Infections Linked Data Platform enables epidemiological investigations, identifying virus-specific risk groups, risk factors, clinical presentation, viral testing patterns, long-term impacts and accurate measures of viral incidence rates in risk and population sub-groups This will not only aid in the calculation of cost-effectiveness estimates of interventions such as immunisations, but also provide guidance for design and implementation of such programs to priority groups. The Respiratory Infections Linked Data Platform will also enable evaluation of the direct and indirect effects of maternal and infant vaccines and new therapeutics. Analyses using this platform will also generate epidemiological data needed for other respiratory viruses on the vaccine pipeline such as parainfluenza virus and human metapneumovirus.
西澳大利亚（WA）呼吸道感染关联数据平台是一个基于人群的队列，旨在调查0至10岁儿童呼吸道合胞病毒（RSV）及其他呼吸道感染的流行病学情况，纳入了微生物检测模式、住院情况、急诊科就诊情况以及社会人口统计学数据。
该队列通过西澳大利亚卫生部的数据集之间的个体关联形成，这些数据集包括出生和死亡登记处、助产士通报系统（MNS）、医院发病率数据收集、急诊科数据收集、西澳大利亚法定传染病数据库、西澳大利亚发育异常登记处、西澳大利亚脑瘫登记处、西澳大利亚产前疫苗接种数据库、西澳大利亚家庭关系数据库以及PathWest呼吸道病毒监测数据。住院和急诊科就诊情况在时间上与常规呼吸道病毒监测数据相关联。
该队列包括2010年1月1日至2020年12月31日期间在西澳大利亚出生的368,830例婴儿及其围产期和人口统计学数据，并对其进行了至2022年6月30日的二级护理随访。在这些出生的婴儿中，有24,660例（6.7%）被认定为原住民。在研究期间（2010 - 2020年），共有4,077例（1.1%）儿童死于各种原因，9.2%（33,818例）儿童早产（<37周）。
呼吸道感染关联数据平台能够进行流行病学调查，识别特定病毒的风险群体、风险因素、临床表现、病毒检测模式、长期影响以及风险和人群亚组中病毒发病率的准确测量。这不仅有助于计算免疫等干预措施的成本效益估计，还能为针对优先群体的此类项目的设计和实施提供指导。呼吸道感染关联数据平台还将能够评估母婴疫苗和新疗法的直接和间接影响。使用该平台进行的分析还将生成针对其他处于疫苗研发阶段的呼吸道病毒（如副流感病毒和人偏肺病毒）所需的流行病学数据。
