Olczyk Pawel, Mencner Łukasz, Komosinska-Vassev Katarzyna
Department of Community Pharmacy, Medical University of Silesia, ul. Kasztanowa 3, 41-200 Sosnowiec, Poland.
Department of Clinical Chemistry and Laboratory Diagnostics, Medical University of Silesia, ul. Jednosci 8, 41-200 Sosnowiec, Poland.
Biomed Res Int. 2014;2014:747584. doi: 10.1155/2014/747584. Epub 2014 Mar 17.
Wound healing is the physiologic response to tissue trauma proceeding as a complex pathway of biochemical reactions and cellular events, secreted growth factors, and cytokines. Extracellular matrix constituents are essential components of the wound repair phenomenon. Firstly, they create a provisional matrix, providing a structural integrity of matrix during each stage of healing process. Secondly, matrix molecules regulate cellular functions, mediate the cell-cell and cell-matrix interactions, and serve as a reservoir and modulator of cytokines and growth factors' action. Currently known mechanisms, by which extracellular matrix components modulate each stage of the process of soft tissue remodeling after injury, have been discussed.
伤口愈合是机体对组织创伤的生理反应，通过一系列复杂的生化反应、细胞活动、分泌的生长因子和细胞因子来实现。细胞外基质成分是伤口修复现象的重要组成部分。首先，它们形成一个临时基质，在愈合过程的每个阶段提供基质的结构完整性。其次，基质分子调节细胞功能，介导细胞-细胞和细胞-基质相互作用，并作为细胞因子和生长因子作用的储存库和调节剂。本文讨论了目前已知的细胞外基质成分调节损伤后软组织重塑过程各阶段的机制。
