Uyenoyama M, Feldman M W, Cavalli-Sforza L L
Proc Natl Acad Sci U S A. 1979 Jan;76(1):420-4. doi: 10.1073/pnas.76.1.420.
Two models involving non-Mendelian transmission of a discrete valued trait through within- and across-generation contagion are proposed in an investigation of the joint evolution of phenotype and genotype. A single locus with two alleles determines susceptibility to contagion. The incorporation of within-generation contagious transmission extends the parameter ranges allowing phenotypic polymorphism and introduces a new phenotypic equilibrium configuration. The latter is characterized by a threshold in the initial value of the trait which determines whether the trait can increase. Phenotypic evolution is accelerated by within-generation contagion, but the rate of genetic evolution is retarded relative to that under uniparental transmission across generations. The second model studied allows the trait to be acquired, at genotype-dependent rates, even if the transmitting parent does not have the trait. Both the pattern of phenotypic transmission and the selection on the trait influence the course of evolution. Some important aspects of the structure of the one locus-two allele model are shown to be preserved with more alleles. At equilibrium, the leading eigenvalue of the transmission-selection matrix assumes the role of genotypic fitness.
在一项关于表型和基因型联合进化的研究中，提出了两种涉及离散值性状通过代内和代际传染进行非孟德尔式传递的模型。一个具有两个等位基因的单基因座决定了对传染的易感性。代内传染传播的纳入扩展了参数范围，允许表型多态性，并引入了一种新的表型平衡构型。后者的特征是性状初始值中的一个阈值，该阈值决定了性状是否能够增加。代内传染加速了表型进化，但相对于跨代单亲传递而言，遗传进化的速率受到了抑制。所研究的第二个模型允许即使传递亲本没有该性状，该性状也能以基因型依赖的速率被获得。表型传递模式和对性状的选择都会影响进化过程。单基因座 - 两个等位基因模型结构的一些重要方面在有更多等位基因时仍得以保留。在平衡状态下，传递 - 选择矩阵的主导特征值承担了基因型适合度的角色。
