Sun Yuling, Tao Yong, Cao Qingchen, Huang Yanbin
Key Laboratory of Advanced Materials (MOE), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
Chem Commun (Camb). 2017 May 4;53(37):5139-5142. doi: 10.1039/c7cc02399e.
Foscarnet sodium is an antiviral drug for the treatment of CMV retinitis, currently in the form of twice-weekly intravitreal injection. Here we developed foscarnet calcium microcrystals as the drug depot, and using the rabbit model we demonstrated that the injected microcrystals maintained a therapeutically relevant drug concentration in the vitreous for more than 3 months.
膦甲酸钠是一种用于治疗巨细胞病毒性视网膜炎的抗病毒药物，目前采用每周两次玻璃体内注射的形式。在此，我们研发了膦甲钙微晶作为药物储存库，并利用兔模型证明，注射的微晶在玻璃体内可维持治疗相关药物浓度超过3个月。
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