另一种在人体内估计遗传损伤的方法。
Another approach to in vivo estimation of genetic damage in humans.
作者信息
Pero R W, Mitelman F
出版信息
Proc Natl Acad Sci U S A. 1979 Jan;76(1):462-3. doi: 10.1073/pnas.76.1.462.
Abstract
Direct measurements of the genetic hazards to man have been determined previously by the appearance of elevated in vivo levels of chromosome aberrations. Here we report that interindividual variations in N-acetoxy-2-acetyl-aminofluorene-induced unscheduled DNA synthesis values parallel the actual in vivo levels of chromosome damage and, therefore, may be a rapid useful supplement in genetic risk assessment for humans.
摘要
先前已通过体内染色体畸变水平升高的现象来确定对人类的遗传危害的直接测量值。在此我们报告，N-乙酰氧基-2-乙酰氨基芴诱导的程序外DNA合成值的个体间差异与实际的体内染色体损伤水平平行，因此，在人类遗传风险评估中可能是一种快速有用的补充方法。
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High blood pressure related to carcinogen-induced unscheduled DNA synthesis, DNA carcinogen binding, and chromosomal aberrations in human lymphocytes.高血压与致癌物诱导的人类淋巴细胞非程序性DNA合成、DNA致癌物结合及染色体畸变有关。
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