Belgian Health Care Knowledge Centre (KCE)
Belgian Health Care Knowledge Centre (KCE).
Int J Technol Assess Health Care. 2017 Jan;33(1):76-83. doi: 10.1017/S0266462317000162. Epub 2017 Apr 24.
Some experts have promoted preparticipative cardiovascular screening programs for young athletes and have claimed that such programs were cost-effective without performing a critical analysis of studies supporting this statement. In this systematic review, a critical assessment of economic evaluations on these programs is performed to determine if they really provide value for money.
A systematic review of economic evaluations was performed on December 24, 2014. Web sites of health technology assessment agencies, the Cochrane database of systematic review, the National Health Service Economic Evaluation Database of the Cochrane Library, EMBASE, Medline, Psychinfo, and EconLit were searched to retrieve (reviews of) economic evaluations. No language or time restrictions were imposed and predefined selection criteria were used. Selected studies were critically assessed applying a structured data extraction sheet.
Five relevant economic evaluations were critically assessed. Results of these studies were mixed. However, those in favor of screening made (methodological) incorrect choices, of which the most important one was not taking into account a no-screening alternative as comparator. Compared with no screening, other strategies (history and physical examination or history and physical examination plus electrocardiogram) were not considered cost-effective.
Results of primary economic evaluations should not be blindly copied without critical assessment. Economic evaluations in this field lack the support of robust evidence. Negative consequences of screening (false positive findings, overtreatment) should also be taken into account and may cause more harm than good. A mass screening of young athletes for cardiovascular diseases does not provide value for money and should be discouraged.
一些专家提倡对年轻运动员进行参赛前心血管筛查项目,并声称这些项目具有成本效益,而没有对支持这一说法的研究进行批判性分析。在本次系统评价中,对这些项目的经济评估进行了批判性评估,以确定它们是否真的物有所值。
我们于 2014 年 12 月 24 日对经济评估的系统评价进行了检索。检索了卫生技术评估机构的网站、考科兰协作网的系统评价数据库、考科兰图书馆的英国国家卫生服务经济评价数据库、EMBASE、Medline、PsycINFO 和 EconLit,以检索(综述的)经济评估。没有对语言或时间进行限制,并使用了预先定义的选择标准。使用结构化的数据提取表对选定的研究进行了批判性评估。
对 5 项相关的经济评估进行了批判性评估。这些研究的结果存在差异。然而,那些支持筛查的研究做出了(方法学上)不正确的选择,其中最重要的一个选择是没有将不筛查作为对照纳入考虑。与不筛查相比,其他策略(病史和体检或病史和体检加心电图)被认为不具有成本效益。
在没有批判性评估的情况下,不应盲目复制初级经济评估的结果。该领域的经济评估缺乏可靠证据的支持。筛查的负面后果(假阳性发现、过度治疗)也应加以考虑,可能弊大于利。对年轻运动员进行心血管疾病的大规模筛查不具有成本效益,应予以劝阻。