Graduate School of Pharmaceutical Sciences, Osaka University , Yamada-oka 1-6, Suita, Osaka 565-0871, Japan.
Org Lett. 2017 May 5;19(9):2422-2425. doi: 10.1021/acs.orglett.7b00985. Epub 2017 Apr 24.
Metal-catalyzed cycloisomerization reactions of 1,n-enynes have become conceptually and chemically attractive processes in the search for atom economy, which is a key subject of current research. However, metal-catalyzed cycloisomerization between aryl enol ether and silylalkynes has not been developed. The ruthenium hydride complex catalyzed cycloisomerization between aryl enol ether and silylalkynes is reported to give benzofurans having useful functional groups, vinyl and trimethylsilylmethyl, on the 2- and 3-positions, respectively.
金属催化的 1,n-烯炔环异构化反应在寻找原子经济性方面具有概念上和化学上的吸引力，这是当前研究的一个关键课题。然而，芳基烯基醚与硅基炔烃之间的金属催化环异构化尚未得到发展。报道了钌氢配合物催化芳基烯基醚与硅基炔烃的环异构化反应，得到了具有有用官能团的苯并呋喃，分别在 2-和 3-位上具有乙烯基和三甲基甲硅烷基甲基。
