Liu Bao-Cheng, Ji Guang
1 Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine , Shanghai, China .
2 Institute of Digestive Disease, China-Canada Center of Research for Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine , Shanghai, China .
J Altern Complement Med. 2017 Jul;23(7):502-504. doi: 10.1089/acm.2016.0383. Epub 2017 Apr 24.
Incorporating "-omics" studies with environmental interactions could help elucidate the biological mechanisms responsible for Traditional Chinese Medicine (TCM) patterns. Based on the authors' own experiences, this review outlines a model of an ideal combination of "-omics" biomarkers, environmental factors, and TCM pattern classifications; provides a narrative review of the relevant genetic and TCM studies; and lists several successful integrative examples. Two integration tools are briefly introduced. The first is the integration of modern devices into objective diagnostic methods of TCM patterning, which would improve current clinical decision-making and practice. The second is the use of biobanks and data platforms, which could broadly support biological and medical research. Such efforts will transform current medical management and accelerate the progression of precision medicine.
将“组学”研究与环境相互作用相结合，有助于阐明中医证型背后的生物学机制。基于作者自身经验，本综述概述了一个“组学”生物标志物、环境因素与中医证型分类理想结合的模型；对相关遗传学和中医研究进行了叙述性综述；并列举了几个成功的整合实例。简要介绍了两种整合工具。第一种是将现代设备整合到中医辨证的客观诊断方法中，这将改善当前的临床决策和实践。第二种是利用生物样本库和数据平台，这可为生物学和医学研究提供广泛支持。这些努力将改变当前的医疗管理方式，加速精准医学的发展。
