125I标记的α-银环蛇毒素在烟草天蛾正常和去传入神经触角叶中的结合位点分布。
Distribution of binding sites for 125I-labeled alpha-bungarotoxin in normal and deafferented antennal lobes of Manduca sexta.
作者信息
Hildebrand J G, Hall L M, Osmond B C
出版信息
Proc Natl Acad Sci U S A. 1979 Jan;76(1):499-503. doi: 10.1073/pnas.76.1.499.
Abstract
125I-Labeled alpha-bungarotoxin has been used to determine the distribution of putative acetylcholine receptors in normal and chronically deafferented antennal lobes in the brain of the moth Manduca sexta. Toxin-binding sites are confined to synaptic regions in deafferented lobes. These findings suggest that receptors can develop in the insect central nervous system independently of normal synaptic influences.
摘要
125I标记的α-银环蛇毒素已被用于确定烟草天蛾大脑中正常和长期去传入神经的触角叶中假定的乙酰胆碱受体的分布。毒素结合位点局限于去传入神经叶的突触区域。这些发现表明，受体可以在昆虫中枢神经系统中独立于正常突触影响而发育。
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