多瘤病毒中非编码序列的复制特别会增强小鼠胸腺肿瘤的发展。
Duplication of noncoding sequences in polyomavirus specifically augments the development of thymic tumors in mice.
作者信息
Freund R, Dawe C J, Benjamin T L
机构信息
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115.
出版信息
J Virol. 1988 Oct;62(10):3896-9. doi: 10.1128/JVI.62.10.3896-3899.1988.
Abstract
A 40-base-pair duplication of noncoding sequences in polyomavirus specifically augmented the development of thymic epitheliomas following inoculation of virus into newborn mice. Virus strains carrying only one copy of this sequence induced a full spectrum of tumors except for overt thymic tumors. This 40-base-pair repeat, on the early side of the replication origin, constituted a tissue-specific regulatory determinant for tumor induction.
摘要
多瘤病毒中非编码序列的40个碱基对重复片段，在将病毒接种到新生小鼠体内后，特别增强了胸腺上皮瘤的发生。仅携带该序列一个拷贝的病毒株能诱发除明显胸腺肿瘤外的全谱肿瘤。位于复制起点早期一侧的这个40碱基对重复序列，构成了肿瘤诱导的组织特异性调控决定因素。
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本文引用的文献
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