Veterans Research and Education Foundation, VA Medical Center, Oklahoma City, Oklahoma, USA.
Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland, USA.
Obesity (Silver Spring). 2017 Jun;25(6):1061-1068. doi: 10.1002/oby.21852. Epub 2017 Apr 24.
Obesity is a contributing factor to insulin resistance and type 2 diabetes. The aim of this study was to study the therapeutic potential of intestinal electrical stimulation (IES) for obesity and associated glucose intolerance and insulin resistance in diet-induced obesity (DIO) rats.
DIO rats were divided into two groups to receive sham or IES for 8 weeks. Oral glucose tolerance and insulin tolerance tests were performed. Gastric emptying and small bowel transit tests were performed. Blood samples were collected for the analysis of insulin and free fatty acid (FFA).
Chronic IES reduced food intake and body weight and decreased the adiposity index in DIO rats. Compared with chow-fed rats, DIO rats had an elevated fasting plasma glucose level, impaired glucose tolerance, and impaired insulin sensitivity, which were improved after chronic IES. FFA was elevated in DIO rats and suppressed with IES. Chronic IES delayed gastric emptying but accelerated small bowel transit.
IES reduces food intake and body weight and improves glucose tolerance and insulin resistance in DIO rats. The ameliorating effect on glycemic control may be due to the weight loss and suppression of plasma FFA. Other mechanisms such as the modulation of gastrointestinal transit may also be involved.
肥胖是导致胰岛素抵抗和 2 型糖尿病的一个因素。本研究旨在研究肠道电刺激（IES）治疗饮食诱导肥胖（DIO）大鼠肥胖及其相关葡萄糖不耐受和胰岛素抵抗的潜力。
将 DIO 大鼠分为假手术或 IES 治疗 8 周两组。进行口服葡萄糖耐量和胰岛素耐量试验。进行胃排空和小肠转运试验。采集血液样本分析胰岛素和游离脂肪酸（FFA）。
慢性 IES 减少了 DIO 大鼠的食物摄入量和体重，并降低了肥胖指数。与正常饮食的大鼠相比，DIO 大鼠的空腹血糖水平升高，葡萄糖耐量受损，胰岛素敏感性降低，这些在慢性 IES 后得到改善。DIO 大鼠的 FFA 升高，IES 可抑制 FFA。慢性 IES 可延缓胃排空，但加速小肠转运。
IES 可减少 DIO 大鼠的食物摄入量和体重，改善其葡萄糖耐量和胰岛素抵抗。对血糖控制的改善可能是由于体重减轻和血浆 FFA 的抑制。其他机制，如胃肠道转运的调节，也可能参与其中。
