Majidinia Maryam, Yousefi Bahman
Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Molecular Targeting Therapy Research Group, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
DNA Repair (Amst). 2017 Jun;54:22-29. doi: 10.1016/j.dnarep.2017.03.009. Epub 2017 Apr 21.
DNA damage/repair constitutes several key pathways working in concert to eliminate DNA lesions and maintain genome stability and integrity. Defective components in DNA damage and repair machinery are an underlying cause for the development and progression of different types of cancers, and breast cancer is no exception. In this paper, we will briefly explain the importance of DNA damage and repair, introduce the current classification schemes for breast cancer, and review the known defects in the repair machinery that have been associated with the risk of breast cancer. Finally, we discuss how the understanding of these pathways can help to design therapeutics for specific targeting of breast cancer tumors.
DNA损伤/修复由几个协同作用的关键途径组成，以消除DNA损伤并维持基因组的稳定性和完整性。DNA损伤和修复机制中的缺陷成分是不同类型癌症发生和发展的根本原因，乳腺癌也不例外。在本文中，我们将简要解释DNA损伤和修复的重要性，介绍目前乳腺癌的分类方案，并综述与乳腺癌风险相关的修复机制中已知的缺陷。最后，我们讨论对这些途径的理解如何有助于设计针对乳腺癌肿瘤的特异性治疗方法。
