• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

畸形胎儿的放射影像学检查：我们能了解到什么？

Radiological imaging of teratological fetuses: what can we learn?

作者信息

Boer Lucas L, Schepens-Franke A N, van Asten J J A, Bosboom D G H, Kamphuis-van Ulzen K, Kozicz T L, Ruiter D J, Oostra R-J, Klein W M

机构信息

Department of Anatomy and Museum for Anatomy and Pathology, Radboud University Medical Centre, Geert Grooteplein Noord 21, 6525 EZ, Nijmegen, The Netherlands.

Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.

出版信息

Insights Imaging. 2017 Jun;8(3):301-310. doi: 10.1007/s13244-017-0551-8. Epub 2017 Apr 24.

DOI:10.1007/s13244-017-0551-8
PMID:28439719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5438317/
Abstract

OBJECTIVES

To determine the advantages of radiological imaging of a collection of full-term teratological fetuses in order to increase their scientific and educational value. BACKGROUND : Anatomical museums around the world exhibit full-term teratological fetuses. Unfortunately, these museums are regularly considered as "morbid cabinets". Detailed dysmorphological information concerning the exhibited specimens is often lacking. Moreover, fetuses with severe and complex congenital anomalies are frequently diagnosed incompletely, incorrectly or not at all.

METHODS

In order to verify diagnoses and to enrich their educational and scientific value, we imaged 41 out of the 72 teratological specimens present in the collection of our Anatomy and Pathology Museum in Nijmegen (The Netherlands) by means of magnetic resonance imaging (MRI) and computed tomography (CT). Additionally, contemporary dysmorphological insights and 3D models are implemented in the teratology education of medical students and residents.

CONCLUSIONS

Full-term teratological fetuses have become increasingly rare and deserve a prominent place in every anatomical museum; they are suitable for contemporary teratological research and education. Modern radiological techniques markedly enhance their scientific and didactic value.

TEACHING POINTS

• To explore the scientific and educational potential of institutionalised teratological collections • To understand the additional value of radiological imaging in diagnosing teratological specimens • To learn about the specific settings of MRI parameters when scanning fixed specimens • To recognise specific internal dysmorphology in several congenital anomalies.

摘要

目的

确定对足月畸形胎儿进行影像学检查的优势，以提高其科学和教育价值。背景：世界各地的解剖博物馆都陈列有足月畸形胎儿标本。遗憾的是，这些博物馆常被视为“病态陈列柜”。展出标本的详细畸形学信息往往缺失。此外，患有严重复杂先天性异常的胎儿常常诊断不完整、不正确或根本未被诊断。

方法

为了核实诊断并丰富其教育和科学价值，我们对荷兰奈梅亨解剖与病理博物馆收藏的72例畸形标本中的41例进行了磁共振成像（MRI）和计算机断层扫描（CT）检查。此外，在医学生和住院医师的畸形学教育中融入了当代畸形学见解和三维模型。

结论

足月畸形胎儿越来越罕见，在每个解剖博物馆都应占据显著位置；它们适用于当代畸形学研究和教育。现代放射技术显著提高了它们的科学和教学价值。

教学要点

• 探索机构化畸形标本收藏的科学和教育潜力 • 了解放射成像在诊断畸形标本中的附加价值 • 学习扫描固定标本时MRI参数的具体设置 • 识别几种先天性异常中的特定内部畸形。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/30dfd5c03bb1/13244_2017_551_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/f06c4b49bc37/13244_2017_551_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/e94b20c5922d/13244_2017_551_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/27fd8231afce/13244_2017_551_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/e8af67479992/13244_2017_551_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/7650e05ec067/13244_2017_551_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/f18897ae2c5b/13244_2017_551_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/30dfd5c03bb1/13244_2017_551_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/f06c4b49bc37/13244_2017_551_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/e94b20c5922d/13244_2017_551_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/27fd8231afce/13244_2017_551_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/e8af67479992/13244_2017_551_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/7650e05ec067/13244_2017_551_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/f18897ae2c5b/13244_2017_551_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b1d/5438317/30dfd5c03bb1/13244_2017_551_Fig7_HTML.jpg

相似文献

1
Radiological imaging of teratological fetuses: what can we learn?畸形胎儿的放射影像学检查：我们能了解到什么？
Insights Imaging. 2017 Jun;8(3):301-310. doi: 10.1007/s13244-017-0551-8. Epub 2017 Apr 24.
2
History and highlights of the teratological collection in the Museum Anatomicum of Leiden University, The Netherlands.荷兰莱顿大学解剖博物馆中畸形学藏品的历史与亮点。
Am J Med Genet A. 2018 Mar;176(3):618-637. doi: 10.1002/ajmg.a.38617. Epub 2018 Feb 5.
3
History and highlights of the teratological collection in the Narrenturm, Vienna (Austria).奥地利维也纳疯人塔畸形学藏品的历史与亮点
Am J Med Genet A. 2023 May;191(5):1301-1324. doi: 10.1002/ajmg.a.63153. Epub 2023 Feb 20.
4
Digital data and the 19th century teratology collection.数字数据与19世纪畸形学藏品
J Audiov Media Med. 1999 Dec;22(4):186-94. doi: 10.1080/014051199101972.
5
Congenital anomalies in the teratological collection of Museum Vrolik in Amsterdam, The Netherlands. II: Skeletal dysplasias.荷兰阿姆斯特丹弗罗利克博物馆畸形学藏品中的先天性异常。II：骨骼发育异常。
Am J Med Genet. 1998 May 1;77(2):116-34.
6
Congenital anomalies in the teratological collection of Museum Vrolik in Amsterdam, The Netherlands. I: Syndromes with multiple congenital anomalies.荷兰阿姆斯特丹弗罗利克博物馆畸形学藏品中的先天性异常。I：伴有多种先天性异常的综合征。
Am J Med Genet. 1998 May 1;77(2):100-15.
7
Congenital anomalies in the teratological collection of Museum Vrolik in Amsterdam, The Netherlands. III: primary field defects, sequences, and other complex anomalies.荷兰阿姆斯特丹弗罗利克博物馆畸形学藏品中的先天性异常。III：原发性场缺陷、序列征及其他复杂异常。
Am J Med Genet. 1998 Oct 30;80(1):46-59. doi: 10.1002/(sici)1096-8628(19981102)80:1<46::aid-ajmg8>3.0.co;2-l.
8
Congenital anomalies in the teratological collection of Museum Vrolik in Amsterdam, The Netherlands. V: conjoined and acardiac twins.荷兰阿姆斯特丹弗罗利克博物馆畸形学藏品中的先天性异常。第五部分：联体双胎和无心畸形双胎。
Am J Med Genet. 1998 Oct 30;80(1):74-89.
9
Frederik Ruysch (1638-1731): Historical perspective and contemporary analysis of his teratological legacy.弗雷德里克·鲁伊斯克（1638 - 1731）：对其畸形学遗产的历史视角与当代分析
Am J Med Genet A. 2017 Jan;173(1):16-41. doi: 10.1002/ajmg.a.37663. Epub 2016 Apr 29.
10
A parapagus dicephalus tripus tribrachius conjoined twin with a unique morphological pattern: a case report.一例具有独特形态模式的三头三臂胸腹联体双胎：病例报告
J Med Case Rep. 2020 Oct 3;14(1):176. doi: 10.1186/s13256-020-02501-x.

引用本文的文献

1
When Teratology and Augmented Reality Entwine: A Qualitative Phenomenological Analysis in a Museal Setting.当畸形学与增强现实交织：博物馆环境中的质性现象学分析
Sensors (Basel). 2025 Jun 12;25(12):3683. doi: 10.3390/s25123683.
2
Morphological variations on vital systems in a conjoined twin.联体双胞胎重要系统的形态学变异。
Anat Sci Int. 2024 Mar;99(2):225-234. doi: 10.1007/s12565-023-00753-3. Epub 2023 Dec 14.
3
Phenotypically Discordant Anomalies in Conjoined Twins: Quirks of Nature Governed by Molecular Pathways?联体双胎中表型不一致的异常：由分子途径调控的自然奇特性？

本文引用的文献

1
What new life for the Parisian (and European) anatomical and pathological collections? struggle for medical education.巴黎（及欧洲）的解剖学和病理学藏品将迎来怎样的新生命？为医学教育而奋斗。
Clin Anat. 2017 May;30(4):432-433. doi: 10.1002/ca.22795. Epub 2017 Jan 24.
2
Paleodysmorphology and paleoteratology: Diagnosing and interpreting congenital conditions of the skeleton in anthropological contexts.古畸形学与古畸形学：在人类学背景下诊断和解释骨骼先天性疾病。
Clin Anat. 2016 Oct;29(7):878-91. doi: 10.1002/ca.22769. Epub 2016 Sep 7.
3
Hunterian Museum bicentenary: 1813-2013.
Diagnostics (Basel). 2023 Nov 10;13(22):3427. doi: 10.3390/diagnostics13223427.
4
Dutch teratological collections and their artistic portrayals.荷兰畸形学收藏及其艺术表现。
Am J Med Genet C Semin Med Genet. 2021 Jun;187(2):283-295. doi: 10.1002/ajmg.c.31902. Epub 2021 May 13.
5
Characterizing the coalescence area of conjoined twins to elucidate congenital disorders in singletons.描述联体双胞胎的并合区，以阐明 singleton 中的先天性疾病。
Clin Anat. 2021 Sep;34(6):845-858. doi: 10.1002/ca.23725. Epub 2021 Feb 20.
6
A parapagus dicephalus tripus tribrachius conjoined twin with a unique morphological pattern: a case report.一例具有独特形态模式的三头三臂胸腹联体双胎：病例报告
J Med Case Rep. 2020 Oct 3;14(1):176. doi: 10.1186/s13256-020-02501-x.
7
History and highlights of the teratological collection in the Museum Anatomicum of Leiden University, The Netherlands.荷兰莱顿大学解剖博物馆中畸形学藏品的历史与亮点。
Am J Med Genet A. 2018 Mar;176(3):618-637. doi: 10.1002/ajmg.a.38617. Epub 2018 Feb 5.
8
Detection of G1138A Mutation of the FGFR3 Gene in Tooth Material from a 180-Year-Old Museological Achondroplastic Skeleton.180 年历史的博物馆收藏软骨发育不全骨骼牙齿材料中 FGFR3 基因 G1138A 突变的检测
Genes (Basel). 2017 Aug 29;8(9):214. doi: 10.3390/genes8090214.
亨特博物馆二百周年纪念：1813-2013 年。
Br Dent J. 2013 Jul;215(1):41-3. doi: 10.1038/sj.bdj.2013.631.
4
Congenital malformations: from superstition to understanding.
Virchows Arch. 2012 Dec;461(6):609-19. doi: 10.1007/s00428-012-1330-z. Epub 2012 Oct 26.
5
Absence of the spleen(s) in conjoined twins: a diagnostic clue of laterality defects? Radiological study of historical specimens.联体双胞胎的脾脏缺失：侧位缺陷的诊断线索？历史标本的影像学研究。
Pediatr Radiol. 2012 Jun;42(6):653-9. doi: 10.1007/s00247-011-2316-8. Epub 2012 Jan 12.
6
[The facelift of the Vrolik Museum].[弗罗利克博物馆的翻新]
Ned Tijdschr Geneeskd. 2011;155(51):A4241.
7
Post mortem magnetic resonance imaging in the fetus, infant and child: a comparative study with conventional autopsy (MaRIAS Protocol).胎儿、婴儿和儿童死后磁共振成像：与常规尸检的比较研究（MaRIAS 方案）。
BMC Pediatr. 2011 Dec 22;11:120. doi: 10.1186/1471-2431-11-120.
8
The role of medical museums in contemporary medical education.医学博物馆在当代医学教育中的作用。
Anat Sci Educ. 2010 Sep-Oct;3(5):249-53. doi: 10.1002/ase.168.
9
Current techniques in postmortem imaging with specific attention to paediatric applications.现行死后影像学技术，重点关注儿科应用。
Pediatr Radiol. 2010 Feb;40(2):141-52; quiz 259. doi: 10.1007/s00247-009-1486-0. Epub 2009 Dec 16.
10
Tetra-amelia and lung hypo/aplasia syndrome: new case report and review.四肢无肢与肺发育不全/发育不良综合征：新病例报告及文献复习
Am J Med Genet A. 2008 Nov 1;146A(21):2799-803. doi: 10.1002/ajmg.a.32489.