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在使用减肥手术分析与报告结果系统(BAROS)进行评估时,十二指肠转位术在超级肥胖患者中优于胃旁路手术。

Duodenal Switch Is Superior to Gastric Bypass in Patients with Super Obesity when Evaluated with the Bariatric Analysis and Reporting Outcome System (BAROS).

作者信息

Skogar Martin L, Sundbom Magnus

机构信息

Department of Surgical Sciences, Uppsala University, SE-751 85, Uppsala, Sweden.

出版信息

Obes Surg. 2017 Sep;27(9):2308-2316. doi: 10.1007/s11695-017-2680-z.

Abstract

BACKGROUND

It is not clear which bariatric procedure that gives the best outcome for patients with super obesity (body mass index [BMI] > 50 kg/m). This study aims to compare outcomes in patients with super obesity after Roux-en-Y gastric bypass (RYGB) and duodenal switch (BPD/DS) using the Bariatric Analysis and Reporting Outcome System (BAROS) and a local questionnaire for gastrointestinal symptoms.

METHODS

A retrospective mail survey including 211 patients, 98 RYGB and 113 BPD/DS, with a mean follow-up time of 4 years for both groups. Gender distribution, age, and comorbidities were similar. Weight loss, changes in comorbidities, quality of life (QoL), and adverse events were registered, as well as gastrointestinal symptoms.

RESULTS

Preoperative BMI was higher in the BPD/DS group (56 ± 6.7 vs. 52 ± 4.0 kg/m, p < 0.01); despite this, the postoperative BMI was lower (31 ± 5.5 vs. 36 ± 7.1 kg/m, p < 0.01). The effect on diabetes was superior after BPD/DS; otherwise, both groups had a similar reduction in comorbidities. There was no difference in QoL. Adverse events were less common after RYGB (14 vs. 27%). Overall, the BPD/DS group had a superior BAROS score (4.7 ± 2.0 vs. 4.0 ± 2.1, p < 0.05). Dumping was more common after RYGB (p < 0.01), while reflux, diarrhea, fecal incontinence, and problems with malodorous flatus were more common after BPD/DS (all p < 0.05). Frequency of nausea/vomiting and abdominal pain were similar.

CONCLUSION

Patients with super obesity have a better weight reduction and metabolic control with BPD/DS, at the cost of higher incidence of adverse events, compared to patients operated with RYGB.

摘要

背景

目前尚不清楚哪种减肥手术对超级肥胖患者(体重指数[BMI]>50kg/m²)效果最佳。本研究旨在使用减肥分析与报告结果系统(BAROS)以及一份关于胃肠道症状的本地问卷,比较Roux-en-Y胃旁路术(RYGB)和十二指肠转位术(BPD/DS)治疗超级肥胖患者的效果。

方法

一项回顾性邮件调查,纳入211例患者,其中98例行RYGB,113例行BPD/DS,两组平均随访时间均为4年。性别分布、年龄和合并症相似。记录体重减轻情况、合并症变化、生活质量(QoL)、不良事件以及胃肠道症状。

结果

BPD/DS组术前BMI较高(56±6.7 vs. 52±4.0kg/m²,p<0.01);尽管如此,术后BMI较低(31±5.5 vs. 36±7.1kg/m²,p<0.01)。BPD/DS术后对糖尿病的疗效更佳;除此之外,两组合并症的减轻程度相似。生活质量无差异。RYGB术后不良事件较少见(14% vs. 27%)。总体而言,BPD/DS组的BAROS评分更高(4.7±2.0 vs. 4.0±2.1,p<0.05)。RYGB术后倾倒综合征更常见(p<0.01),而BPD/DS术后反流、腹泻、大便失禁和屁臭问题更常见(均p<0.05)。恶心/呕吐和腹痛的发生率相似。

结论

与接受RYGB手术的患者相比,超级肥胖患者接受BPD/DS手术可实现更好的体重减轻和代谢控制,但不良事件发生率更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d25/5562774/62a275688955/11695_2017_2680_Fig1_HTML.jpg

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