• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Editorial: New Insights into a Classical Pathway: Key Roles of the Mevalonate Cascade in Different Diseases (Part II).社论：经典途径的新见解：甲羟戊酸级联反应在不同疾病中的关键作用（第二部分）
Curr Mol Pharmacol. 2017;10(2):74-76. doi: 10.2174/187446721002170301204357.
2
Editorial (Thematic Issue: New Insights into a Classical Pathway: Key Roles of the Mevalonate Cascade in Different Diseases (Part I)).社论（专题：经典途径的新见解：甲羟戊酸级联反应在不同疾病中的关键作用（第一部分））
Curr Mol Pharmacol. 2017;10(1):3-5. doi: 10.2174/1874467209999160114145952.
3
Could drugs inhibiting the mevalonate pathway also target cancer stem cells?抑制甲羟戊酸途径的药物是否也能靶向肿瘤干细胞？
Drug Resist Updat. 2016 Mar;25:13-25. doi: 10.1016/j.drup.2016.02.001. Epub 2016 Feb 20.
4
Mevalonate Cascade and its Regulation in Cholesterol Metabolism in Different Tissues in Health and Disease.甲羟戊酸途径及其在健康与疾病状态下不同组织胆固醇代谢中的调节
Curr Mol Pharmacol. 2017;10(1):13-26. doi: 10.2174/1874467209666160112123746.
5
The mevalonate pathway and renal diseases: experimental and clinical implications.
Int J Artif Organs. 1998 May;21(5):243-6.
6
Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii.抑制甲基戊二酰辅酶A还原酶II类的梅氏假单胞菌。
Protein Sci. 2004 Jun;13(6):1693-7. doi: 10.1110/ps.03597504.
7
Basic and Clinical Observations of Mevalonate Depletion on the Mevalonate Signaling Pathway.甲羟戊酸耗竭对甲羟戊酸信号通路的基础与临床观察
Curr Mol Pharmacol. 2017;10(1):6-12. doi: 10.2174/1874467209666160112125805.
8
Mevalonate Cascade and Neurodevelopmental and Neurodegenerative Diseases: Future Targets for Therapeutic Application.甲羟戊酸途径与神经发育和神经退行性疾病：治疗应用的未来靶点
Curr Mol Pharmacol. 2017;10(2):115-140. doi: 10.2174/1874467209666160112125446.
9
Current insights into pathogenesis of Parkinson's disease: Approach to mevalonate pathway and protective role of statins.目前对帕金森病发病机制的认识：甲羟戊酸途径的研究进展和他汀类药物的保护作用。
Biomed Pharmacother. 2017 Jun;90:724-730. doi: 10.1016/j.biopha.2017.04.038. Epub 2017 Apr 15.
10
Mevalonate deprivation mediates the impact of lovastatin on the differentiation of murine 3T3-F442A preadipocytes.甲羟戊酸剥夺介导洛伐他汀对鼠 3T3-F442A 前脂肪细胞分化的影响。
Exp Biol Med (Maywood). 2014 Mar;239(3):293-301. doi: 10.1177/1535370213517614. Epub 2014 Jan 29.

引用本文的文献

1
A Retrospective Hospital-Based Study of HMGCR Expression in HER2 IHC 2+ and 3+ Breast Cancer.回顾性研究 HMGCR 在 HER2 IHC 2+ 和 3+ 乳腺癌中的表达。
Asian Pac J Cancer Prev. 2021 Jul 1;22(7):2043-2047. doi: 10.31557/APJCP.2021.22.7.2043.
2
Simvastatin Induces Apoptosis in Medulloblastoma Brain Tumor Cells via Mevalonate Cascade Prenylation Substrates.辛伐他汀通过甲羟戊酸级联异戊二烯化底物诱导髓母细胞瘤脑肿瘤细胞凋亡。
Cancers (Basel). 2019 Jul 17;11(7):994. doi: 10.3390/cancers11070994.

本文引用的文献

1
Placenta expresses anti-Müllerian hormone and its receptor: Sex-related difference in fetal membranes.胎盘表达抗苗勒管激素及其受体：胎膜中的性别相关差异。
Placenta. 2015 Jul;36(7):731-7. doi: 10.1016/j.placenta.2015.04.009. Epub 2015 Apr 30.
2
Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins.气管内滴注普伐他汀治疗小鼠过敏性哮喘：一种肺部靶向递送他汀类药物的方法。
Physiol Rep. 2015 May 11;3(5). doi: 10.14814/phy2.12352.
3
Fetal exposure to placental corticotropin-releasing hormone (pCRH) programs developmental trajectories.胎儿暴露于胎盘促肾上腺皮质激素释放激素（pCRH）会设定发育轨迹。
Peptides. 2015 Oct;72:145-53. doi: 10.1016/j.peptides.2015.03.020. Epub 2015 Apr 1.
4
Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins.甲羟戊酸途径抑制导致气道间充质细胞死亡：自噬、未折叠蛋白反应和细胞凋亡的整合，重点关注Bcl2家族蛋白
Biochim Biophys Acta. 2014 Jul;1843(7):1259-71. doi: 10.1016/j.bbamcr.2014.03.006. Epub 2014 Mar 15.
5
Role of the sex hormone estrogen in the prevention of lipid disorder.性激素雌激素在预防脂质紊乱中的作用。
Curr Med Chem. 2014;21(24):2734-42. doi: 10.2174/0929867321666140303123602.
6
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.将甲羟戊酸途径作为心脏病、癌症和肺病的一种新治疗方法。
Pharmacol Ther. 2014 Jul;143(1):87-110. doi: 10.1016/j.pharmthera.2014.02.007. Epub 2014 Feb 26.
7
Testosterone: a vascular hormone in health and disease.睾酮：一种在健康和疾病中的血管激素。
J Endocrinol. 2013 May 7;217(3):R47-71. doi: 10.1530/JOE-12-0582. Print 2013 Jun.
8
Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts.他汀类药物抑制甲羟戊酸通路诱导人心房成纤维细胞死亡过程中的细胞凋亡、自噬和内质网应激
Cell Death Dis. 2012 Jun 21;3(6):e330. doi: 10.1038/cddis.2012.61.
9
The adult asthmatic.成人哮喘。
Clin Rev Allergy Immunol. 2012 Aug;43(1-2):138-55. doi: 10.1007/s12016-011-8260-4.
10
Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research.他汀类药物、代谢途径与哮喘：一个有待进一步研究的治疗契机。
Drug Metab Lett. 2011 Jan;5(1):40-4. doi: 10.2174/187231211794455217.

Editorial: New Insights into a Classical Pathway: Key Roles of the Mevalonate Cascade in Different Diseases (Part II).

作者信息

Zeki Amir A, Yeganeh Behzad, Kenyon Nicholas J, Ghavami Saeid

机构信息

Assistant Professor of Medicine Division of Pulmonary, Critical Care and Sleep Medicine Department of Internal Medicine Center for Comparative Respiratory Biology and Medicine University of California, Davis School of Medicine Davis, CA 95616, United States.

Department of Physiology and Experimental Medicine Hospital for Sick Children Research Institute University of Toronto Toronto M5G 0A4, Canada.

出版信息

Curr Mol Pharmacol. 2017;10(2):74-76. doi: 10.2174/187446721002170301204357.

DOI:10.2174/187446721002170301204357
PMID:28440195
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6018051/
Abstract
摘要