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Editorial (Thematic Issue: New Insights into a Classical Pathway: Key Roles of the Mevalonate Cascade in Different Diseases (Part I)).

作者信息

Ghavami Saeid, Kenyon Nicholas J, Yeganeh Behzad, Zeki Amir A

机构信息

Department of Human Anatomy and Cell Sciences, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, 130-745 Bannatyne Ave., Winnipeg, MB R3E 0J9. Canada.

Division of Pulmonary, Critical Care, Sleep Medicine Department of Internal Medicine Center for Comparative Respiratory Biology and Medicine University of California, Davis School of Medicine Davis, CA 95616. United States.

出版信息

Curr Mol Pharmacol. 2017;10(1):3-5. doi: 10.2174/1874467209999160114145952.

DOI:10.2174/1874467209999160114145952
PMID:26768962
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6111027/
Abstract
摘要

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本文引用的文献

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Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins.气管内滴注普伐他汀治疗小鼠过敏性哮喘：一种肺部靶向递送他汀类药物的方法。
Physiol Rep. 2015 May 11;3(5). doi: 10.14814/phy2.12352.
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Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins.甲羟戊酸途径抑制导致气道间充质细胞死亡：自噬、未折叠蛋白反应和细胞凋亡的整合，重点关注Bcl2家族蛋白
Biochim Biophys Acta. 2014 Jul;1843(7):1259-71. doi: 10.1016/j.bbamcr.2014.03.006. Epub 2014 Mar 15.
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Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.将甲羟戊酸途径作为心脏病、癌症和肺病的一种新治疗方法。
Pharmacol Ther. 2014 Jul;143(1):87-110. doi: 10.1016/j.pharmthera.2014.02.007. Epub 2014 Feb 26.
4
Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts.他汀类药物抑制甲羟戊酸通路诱导人心房成纤维细胞死亡过程中的细胞凋亡、自噬和内质网应激
Cell Death Dis. 2012 Jun 21;3(6):e330. doi: 10.1038/cddis.2012.61.
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Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts.辛伐他汀抑制人呼吸道成纤维细胞中 TGFβ1 诱导的纤连蛋白。
Respir Res. 2011 Aug 24;12(1):113. doi: 10.1186/1465-9921-12-113.
6
Chronic obstructive pulmonary disease: patho-physiology, current methods of treatment and the potential for simvastatin in disease management.慢性阻塞性肺疾病：病理生理学、当前的治疗方法以及辛伐他汀在疾病管理中的潜力。
Expert Opin Drug Deliv. 2011 Sep;8(9):1205-20. doi: 10.1517/17425247.2011.588697. Epub 2011 May 26.
7
The adult asthmatic.成人哮喘。
Clin Rev Allergy Immunol. 2012 Aug;43(1-2):138-55. doi: 10.1007/s12016-011-8260-4.
8
Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53.甲羟戊酸途径调控气道间质细胞自噬和凋亡：p53 的双重作用。
PLoS One. 2011 Jan 31;6(1):e16523. doi: 10.1371/journal.pone.0016523.
9
Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research.他汀类药物、代谢途径与哮喘：一个有待进一步研究的治疗契机。
Drug Metab Lett. 2011 Jan;5(1):40-4. doi: 10.2174/187231211794455217.
10
The mevalonate cascade as a target to suppress extracellular matrix synthesis by human airway smooth muscle.甲羟戊酸途径作为抑制人呼吸道平滑肌细胞外基质合成的靶点。
Am J Respir Cell Mol Biol. 2011 Mar;44(3):394-403. doi: 10.1165/rcmb.2010-0052OC. Epub 2010 May 12.