Editorial (Thematic Issue: New Insights into a Classical Pathway: Key Roles of the Mevalonate Cascade in Different Diseases (Part I)).
作者信息
Ghavami Saeid, Kenyon Nicholas J, Yeganeh Behzad, Zeki Amir A
机构信息
Department of Human Anatomy and Cell Sciences, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, 130-745 Bannatyne Ave., Winnipeg, MB R3E 0J9. Canada.
Division of Pulmonary, Critical Care, Sleep Medicine Department of Internal Medicine Center for Comparative Respiratory Biology and Medicine University of California, Davis School of Medicine Davis, CA 95616. United States.
出版信息
Curr Mol Pharmacol. 2017;10(1):3-5. doi: 10.2174/1874467209999160114145952.
Abstract
摘要
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Curr Mol Pharmacol. 2017;10(1):3-5. doi: 10.2174/1874467209999160114145952.
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Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins.气管内滴注普伐他汀治疗小鼠过敏性哮喘：一种肺部靶向递送他汀类药物的方法。
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Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins.甲羟戊酸途径抑制导致气道间充质细胞死亡：自噬、未折叠蛋白反应和细胞凋亡的整合，重点关注Bcl2家族蛋白
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Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.将甲羟戊酸途径作为心脏病、癌症和肺病的一种新治疗方法。
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Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts.他汀类药物抑制甲羟戊酸通路诱导人心房成纤维细胞死亡过程中的细胞凋亡、自噬和内质网应激
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Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts.辛伐他汀抑制人呼吸道成纤维细胞中 TGFβ1 诱导的纤连蛋白。
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Chronic obstructive pulmonary disease: patho-physiology, current methods of treatment and the potential for simvastatin in disease management.慢性阻塞性肺疾病：病理生理学、当前的治疗方法以及辛伐他汀在疾病管理中的潜力。
Expert Opin Drug Deliv. 2011 Sep;8(9):1205-20. doi: 10.1517/17425247.2011.588697. Epub 2011 May 26.
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Clin Rev Allergy Immunol. 2012 Aug;43(1-2):138-55. doi: 10.1007/s12016-011-8260-4.
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Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53.甲羟戊酸途径调控气道间质细胞自噬和凋亡：p53 的双重作用。
PLoS One. 2011 Jan 31;6(1):e16523. doi: 10.1371/journal.pone.0016523.
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Am J Respir Cell Mol Biol. 2011 Mar;44(3):394-403. doi: 10.1165/rcmb.2010-0052OC. Epub 2010 May 12.
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