Gorshkova I N, Noeva E A, Polesskiĭ V A, Perova N V, Ruuge E K
Vopr Med Khim. 1988 May-Jun;34(3):85-90.
Thermo-induced structural reorganization in human high density lipoproteins subclasses HDL2 and HDL3 have been studied by means of electronic paramagnetic resonance method. A number of spin labels were used: 5- and 16-DOXYL stearates, DOXYL-labelled derivatives of pentadecane, phosphatidyl choline and sphingomyelin. In hypoalphalipoproteinemia one of the thermo-induced transitions in HDL2 (at 23-30 degrees) was not observed. In coronary heart disease the critical temperature for HDL3 was shifted from the physiological values and located at 42-48 degrees. The data obtained are discussed from the point of view of their potential role in atherogenesis.
利用电子顺磁共振方法研究了人高密度脂蛋白亚类HDL2和HDL3中热诱导的结构重组。使用了多种自旋标记物：5-和16-硬脂酰氧基氮氧自由基、十五烷、磷脂酰胆碱和鞘磷脂的氮氧自由基标记衍生物。在低α脂蛋白血症中，未观察到HDL2中热诱导的转变之一（在23 - 30摄氏度）。在冠心病中，HDL3的临界温度偏离生理值，位于42 - 48摄氏度。从这些数据在动脉粥样硬化发生中的潜在作用角度对所得数据进行了讨论。
