Panasenko O M, Azizova O A, Torkhovskaia T I, Dudaev V A
Vopr Med Khim. 1984;30(6):40-5.
Structural properties of lipoprotein organization in blood plasma of the patients with ischemic heart disease have been studied by means of electronic paramagnetic resonance method, using a derivate of stearic acid (5-doxylsteararte) as a spin probe. Significant differences in the patterns of thermo-induced structural reorganizations of all the lipoprotein types in normal and pathological states were shown. However, these differences were not found in the lipids isolated from the lipoproteins. In high density lipoproteins HDL2 and HDL3 from blood plasma of the patients with ischemic heart disease a decrease in the micro-environment polarity was shown to take place at the depth of 8 A from the lipoprotein surface. The data obtained suggest the distinct changes in structural organization of all the lipoprotein types in heart ischemic disease, which appear to occur as a result of modification of apoproteins and/or protein-lipid interactions in lipoproteins.
采用电子顺磁共振方法，以硬脂酸衍生物（5-硬脂酰氧基硬脂酸酯）作为自旋探针，研究了缺血性心脏病患者血浆中脂蛋白组织的结构特性。结果显示，正常状态和病理状态下所有脂蛋白类型的热诱导结构重组模式存在显著差异。然而，从脂蛋白中分离出的脂质并未发现这些差异。在缺血性心脏病患者血浆的高密度脂蛋白HDL2和HDL3中，距脂蛋白表面8埃深处的微环境极性降低。所得数据表明，心脏缺血性疾病中所有脂蛋白类型的结构组织发生了明显变化，这似乎是由于载脂蛋白和/或脂蛋白中蛋白质-脂质相互作用的改变所致。
