Xin Chen, Chen Xiaoya, Li Meng, Shi Yan, Wang Huaizhou, Wang Ruikang, Wang Ningli
Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Department of Ophthalmology, Xuzhou 1st Hospital, Jiangsu, China.
Acta Ophthalmol. 2017 Sep;95(6):602-607. doi: 10.1111/aos.13415. Epub 2017 Apr 25.
To describe the use of a newly developed side-viewing catheter probe to provide the cross-sectional images of collector channel entrance (CCE), achieved by swept-source optical coherence tomography (SS-OCT).
A side-viewing SS-OCT catheter probe was developed that has a core probe diameter of 0.15 mm and an outer diameter of 0.25 mm, for the purpose of imaging CCEs within eye globe. Cadaver eyes harvested from swine and human were used to demonstrate its feasibility. For porcine eyes, the probe imaged the CCE by accessing the region of the aqueous plexus (AP) as well as along the inner wall (IW) of the trabecular meshwork (TM). For human eyes, the CCE images were captured by placing the probe within the lumen of the Schlemm's canal (SC) and along its IW.
With the optical coherence tomography (OCT) catheter probe, the CCE is well delineated as optically empty areas within the highly scattering sclera. In porcine eyes, images captured in the region of the AP demonstrate a large cavity with delicate tissue strands around the probe. The CCE can be identified at the outer margin of the AP. When imaged along the IW, the TM is discernable but difficult to be distinguished from the AP. In the human limbal regions, when placed within the lumen of the SC, the catheter probe fully occupies the potential space. TM is highly compact. The CCE can be identified at the outer wall of the SC. When imaged along the IW of TM, the SC and CCE can be identified.
The intraocular SS-OCT catheter probe is feasible to provide the CCE images, indicating useful clinical applications to assist glaucoma surgery.
描述一种新开发的侧视导管探头的应用，该探头通过扫频光学相干断层扫描（SS-OCT）提供集液管入口（CCE）的横截面图像。
开发了一种侧视SS-OCT导管探头，其核心探头直径为0.15毫米，外径为0.25毫米，用于对眼球内的CCE进行成像。使用从猪和人身上获取的尸体眼睛来证明其可行性。对于猪眼，探头通过进入房水丛（AP）区域以及沿着小梁网（TM）的内壁（IW）对CCE进行成像。对于人眼，通过将探头放置在施莱姆管（SC）的管腔内并沿着其IW来捕获CCE图像。
使用光学相干断层扫描（OCT）导管探头，CCE在高度散射的巩膜内被清晰地描绘为光学空洞区域。在猪眼中，在AP区域捕获的图像显示探头周围有一个大腔，腔内有纤细的组织束。CCE可在AP的外缘识别。当沿着IW成像时，TM是可辨别的，但难以与AP区分开。在人角膜缘区域，当放置在SC的管腔内时，导管探头完全占据潜在空间。TM高度致密。CCE可在SC的外壁识别。当沿着TM的IW成像时，SC和CCE均可识别。
眼内SS-OCT导管探头可提供CCE图像，表明其在辅助青光眼手术方面具有有用的临床应用价值。
