Ruiz Department of Ophthalmology and Visual Science, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas; Robert Cizik Eye Clinic, Houston, Texas.
Robert Cizik Eye Clinic, Houston, Texas.
Ophthalmology. 2018 Jul;125(7):994-1002. doi: 10.1016/j.ophtha.2018.01.018. Epub 2018 Feb 21.
To identify the presence or absence of 3 identifiable landmarks: trabecular meshwork (TM), Schlemm's canal (SC), and a novel landmark termed the band of extracanalicular limbal lamina (BELL), which is a landmark adjacent to SC visible on anterior segment (AS) OCT. These landmarks also were analyzed pathologically to identify all 3 landmarks.
Retrospective review.
One eye per participant from prior institutional review board-approved studies in which AS OCT imaging was performed.
Horizontal images from 2-dimensional angle analysis scans using a CASIA SS-1000 (Tomey, Nagoya, Japan) AS OCT were evaluated by masked readers. Logistic regression was used to analyze the potential factors of age, gender, race, intraocular pressure, gonioscopy grade, angle location, and history or presence of surgery on the visibility of these structures. Pathologic correlation on 5 previously enucleated eyes also was performed.
Presence or absence of angle landmarks-TM, SC, and BELL-using Anterior Chamber Analysis and Interpretation software (ACAI, Houston, TX).
Three hundred three angles of 153 horizontal images were included in this study. The mean age was 51.5±16.0 years, with 98 women (64%) and 100 white persons (66%). The outer border of the BELL was observed in 288 angles (95%), TM was found in 220 angles (73%), and SC was seen in 120 angles (40%). The outer border of the BELL was more visible in white persons (P = 0.02) than Asians and in eyes with a Spaeth gonioscopy grade of E than those with a grade of A (P = 0.02). Both TM (P = 0.001) and SC (P = 0.001) were more visible in temporal angles (81% for TM, 49% for SC) than in nasal angles (64% for TM, 30% for SC). Additionally, SC was more visible in open angles (43%) than in narrow angles (27%; P = 0.02). These 3 structures were verified in a pathologic study.
We identified a novel AS OCT landmark adjacent to SC. This structure also was identified on pathologic samples from enucleated eyes. Further study is needed to determine the pathophysiologic relevance of these findings.
识别 3 个可识别的解剖标志的存在或缺失：小梁网（TM）、施莱姆氏管（SC）和一个新的解剖标志称为小梁外限膜带（BELL），这是一个位于眼前节 OCT 上的 SC 旁的解剖标志。这些解剖标志也进行了病理分析以识别所有 3 个解剖标志。
回顾性研究。
每个参与者的一只眼来自先前经过机构审查委员会批准的研究，这些研究中进行了眼前节 OCT 成像。
使用 CASIA SS-1000（Tomey，Nagoya，日本）的二维角度分析扫描的水平图像由盲法读者进行评估。逻辑回归用于分析年龄、性别、种族、眼压、房角分级、角度位置以及手术史或存在对这些结构可见性的潜在因素。还对 5 只先前眼球摘除的眼睛进行了病理相关性研究。
使用前房分析和解释软件（ACAI，休斯顿，TX）评估角部解剖标志-TM、SC 和 BELL 的存在或缺失。
本研究纳入了 153 个水平图像的 303 个角度。平均年龄为 51.5±16.0 岁，其中女性 98 人（64%），白人 100 人（66%）。BELL 的外边界在 288 个角度（95%）中可见，TM 在 220 个角度（73%）中可见，SC 在 120 个角度（40%）中可见。BELL 的外边界在白人中比在亚洲人（P=0.02）和在 Spaeth 房角分级为 E 的眼中比在分级为 A 的眼中更明显（P=0.02）。TM（P=0.001）和 SC（P=0.001）在颞侧（TM 为 81%，SC 为 49%）比在鼻侧（TM 为 64%，SC 为 30%）更明显。此外，SC 在开阔角（43%）比在狭窄角（27%）更明显（P=0.02）。这些 3 个结构在病理研究中得到了验证。
我们在 SC 旁发现了一个新的眼前节 OCT 解剖标志。这个结构也在眼球摘除的病理样本中被发现。需要进一步的研究来确定这些发现的病理生理学相关性。
