Department of Chemistry, The Chinese University of Hong Kong , Shatin, New Territories, Hong Kong SAR.
Org Lett. 2017 May 5;19(9):2446-2449. doi: 10.1021/acs.orglett.7b01085. Epub 2017 Apr 25.
Hydroxytrifluoromethylation of alkenes using the fluoroform (CFH)-derived [CuCF] reagent is described. In the presence of additive BPin and air, this reagent effectively facilitates the addition of hydroxy and trifluoromethyl groups across an alkene double bond, a formal hydroxytrifluoromethylation process. Various β-trifluoromethyl alcohols can be synthesized from simple alkenes where the ultimate CF source is the industrial byproduct fluoroform.
烯的三氟甲基化作用使用氟仿（CFH）衍生的[CuCF]试剂来描述。在添加剂 BPin 和空气的存在下，该试剂有效地促进了羟基和三氟甲基基团在烯烃双键上的加成，这是一种形式的羟三氟甲基化过程。各种β-三氟甲基醇可以由简单的烯烃合成，其中最终的 CF 源是工业副产品氟仿。
