Department of Chemistry, The Chinese University of Hong Kong , Shatin, New Territories, Hong Kong SAR.
J Org Chem. 2017 Jun 16;82(12):6192-6201. doi: 10.1021/acs.joc.7b00755. Epub 2017 May 31.
A domino hydroboration/trifluoromethylation (formal hydrotrifluoromethylation) of alkynes using the fluoroform-derived [CuCF] reagent is achieved. Synthetically useful (E)-alkenyl-CF building blocks and 1,1-bis(trifluoromethyl)-substituted alkenes can be prepared under ambient conditions in one pot/one step from alkynes. The ultimate source of CF is the inexpensive industrial waste fluoroform.
炔烃的级联硼氢化/三氟甲基化（形式上的氢三氟甲基化）反应可以使用由三氟甲烷衍生的[CuCF]试剂来实现。在环境条件下，从炔烃一锅一步可以制备出具有合成用途的（E）-烯基-CF 砌块和 1,1-双（三氟甲基）取代的烯烃。CF 的最终来源是廉价的工业废物三氟甲烷。
