甲状腺癌的表观遗传调节剂
Epigenetic modulators of thyroid cancer.
作者信息
Rodríguez-Rodero Sandra, Delgado-Álvarez Elías, Díaz-Naya Lucía, Martín Nieto Alicia, Menéndez Torre Edelmiro
机构信息
Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain; Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), HUCA, Universidad de Oviedo, Oviedo, Spain.
Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain.
出版信息
Endocrinol Diabetes Nutr. 2017 Jan;64(1):44-56. doi: 10.1016/j.endinu.2016.09.006. Epub 2017 Jan 20.
There are some well known factors involved in the etiology of thyroid cancer, including iodine deficiency, radiation exposure at early ages, or some genetic changes. However, epigenetic modulators that may contribute to development of these tumors and be helpful to for both their diagnosis and treatment have recently been discovered. The currently known changes in DNA methylation, histone modifications, and non-coding RNAs in each type of thyroid carcinoma are reviewed here.
甲状腺癌的病因涉及一些众所周知的因素，包括碘缺乏、早年辐射暴露或某些基因变化。然而，最近发现了一些可能促成这些肿瘤发生并有助于其诊断和治疗的表观遗传调节因子。本文综述了目前已知的各类甲状腺癌中DNA甲基化、组蛋白修饰和非编码RNA的变化。
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