Williams D L, Amborski G F, Davis W C
Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70808.
Am J Vet Res. 1988 Jul;49(7):1098-103.
Monoclonal antibodies and microfluorimetry were used to determine the absolute number of B and T lymphocytes in the blood of bovine leukemia virus (BLV)-infected cows. The blood lymphocyte populations from BLV-infected cows were significantly higher than those from BLV-negative cows. The increase in the lymphocyte population in 3 BLV-infected nonlymphocytotic cows was attributed to a significant increase in the number of T lymphocytes; in 3 BLV-infected persistently lymphocytotic cows, the increase was attributed to a significant increase in the number of B and T lymphocytes. One persistently lymphocytotic cow had a high lymphocyte count, and lymphocytes from this cow contained cells that appeared to stain with markers specific for bovine B and T lymphocytes. We concluded that infection of cattle with the B-cell lymphotropic retrovirus, BLV, not only affected B cells, but also T cells.
利用单克隆抗体和微量荧光测定法来确定感染牛白血病病毒（BLV）的奶牛血液中B淋巴细胞和T淋巴细胞的绝对数量。感染BLV的奶牛的血液淋巴细胞群体显著高于未感染BLV的奶牛。3头感染BLV的非淋巴细胞增多症奶牛的淋巴细胞群体增加归因于T淋巴细胞数量的显著增加；3头感染BLV的持续性淋巴细胞增多症奶牛的淋巴细胞群体增加归因于B淋巴细胞和T淋巴细胞数量的显著增加。1头持续性淋巴细胞增多症奶牛的淋巴细胞计数很高，这头奶牛的淋巴细胞包含似乎能用牛B淋巴细胞和T淋巴细胞特异性标志物染色的细胞。我们得出结论，牛感染嗜B细胞逆转录病毒BLV不仅影响B细胞，也影响T细胞。
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