从土壤放线菌链霉菌WS-13394中分离得到的四种新蒽醌及其生物活性。
Four new anthraquinones from a soil actinomycete Streptomyces sp. WS-13394 and their bioactivities.
作者信息
Wu Zhaoyuan, Zhang Yani, Fang Wei, Shi Liqiao, Wan Zhongyi
机构信息
a Hubei Biopesticide Engineering Research Centre , Hubei Academy of Agricultural Sciences , Wuhan , P. R. China.
出版信息
Nat Prod Res. 2018 Feb;32(4):412-417. doi: 10.1080/14786419.2017.1314285. Epub 2017 Apr 25.
Further chemical study of secondary metabolites from the soil actinomycete Streptomyces sp. WS-13394 resulted in the isolation of four new alkylated anthraquinone analogues (5-8). Their structures were elucidated on the basis of extensive spectroscopic analysis, including HR-ESI-MS, 1D and 2D NMR. The new compounds, together with analogues obtained before (1-4), were tested for their in vitro cytotoxicity against Huh-7 and SGC-7901.
对土壤放线菌链霉菌属WS-13394产生的次生代谢产物进行进一步化学研究，分离得到了四种新的烷基化蒽醌类似物（5 - 8）。通过包括高分辨电喷雾电离质谱（HR-ESI-MS）、一维和二维核磁共振（1D和2D NMR）在内的广泛光谱分析确定了它们的结构。将这些新化合物与之前得到的类似物（1 - 4）一起，测试了它们对Huh-7和SGC-7901的体外细胞毒性。
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