从链霉菌属培养物中分离得到的一种新吡咯并[1,2-a]色烯

A new pyrrolosesquiterpene isolated from cultures of Streptomyces sp.

机构信息

Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.

Northeast Agricultural University, Harbin, China.

出版信息

J Antibiot (Tokyo). 2014 May;67(5):415-7. doi: 10.1038/ja.2014.8. Epub 2014 Feb 19.

DOI:10.1038/ja.2014.8

PMID:24549152

Abstract

One new pyrrolosesquiterpene 1 was isolated from the cultures of the soil actinomycete Streptomyces sp. Hd7-21. Its structure was elucidated by extensive spectroscopic analyses including MS and one-dimensional and two-dimensional NMR data. Compound 1 showed moderate cytotoxic activity against a panel of human cancer cell lines.

摘要

从土壤放线菌 Streptomyces sp. Hd7-21 的培养物中分离得到一种新的吡咯并色烯 1。通过包括 MS 和一维及二维 NMR 数据在内的广泛光谱分析确定了其结构。化合物 1 对一组人癌细胞系表现出中等的细胞毒性活性。